@#Abstract Objective To explore the clinical characteristics of
nucleic acid negative
newborns delivered by
pregnant women infected with
SARS-CoV-2 (Omicron variant BA. 5.1.3) in Sanya area, and to provide evidence for
understanding its clinical characteristics.
Methods A retrospective
analysis was performed on 14
neonates with negative
nucleic acid delivered by
pregnant women who tested positive for
SARS-CoV-2 (Omicron variant BA.5.1.3) in Sanya Central
Hospital (the Third People's
Hospital of Hainan Province) from June 2022 to September 2022 (
observation group, n=14). The corresponding
nucleic acid-negative
newborns delivered by
pregnant women detected negative with
SARS-CoV-2 (Omicronon variant
strain BA.5.1.3) were set as the
control group (n=56), and the general data and clinical characteristics of
neonates in the two groups were compared. Results There was no significant difference between the
observation group and the
control group in
pregnancy diabetes, pregnancy induced hypertension, gestational pre-eclampsia, fetal intrauterine distress, premature
rupture of
membranes (P>0.05); there was no significant difference between the
observation group and the
control group in terms of
sex,
gestational age,
birth weight, age, mode of delivery,
birth Apgar score,
heart screening,
pulmonary disease, glucose 6-phosphate dehydrogenase (G6PD)
deficiency,
thalassemia,
breast milk jaundice, hemolytic jaundice (P>0.05). The
bilirubin level,
blue light irradiation cases and the duration of
blue light irradiation of the
newborns in the
observation group at 7 days after
birth were higher than those in the
control group (P<0.05); the ratio of
blood oxygen saturation ≥ 90% in the
observation group was lower than that in the
control group (21.43% vs 89.29%, P<0.05), and the ratio of
blood oxygen saturation occasionally<90% was higher than that in the
control group (57.14% vs 10.71%, P<0.05). The ratio of
blood oxygen saturation<90% had no significant difference compared with that in the
control group (7.14% vs 0, P>0.05), and the ratio of
blood oxygen saturation reduced to the required
oxygen uptake was higher than that in the
control group (14.29% vs 0, P<0.05). Conclusions The
jaundice manifestation of the
nucleic acid-negative
newborns delivered by
pregnant women infected with
SARS-CoV-2 (Omicronon variant
strain BA.5.1.3) in Sanya area is relatively obvious, with
blood oxygen saturation easily lower than 90% and even requiring
oxygen inhalation in severe cases.