With scarce
resources, natural Bovis
Calculus is expensive and hard to meet clinical demand. At the moment, four kinds of Bovis
Calculus are available on the market the
natural product,
in vitro cultured product, synthesized product, and the product formed in
cow after manual intervention. In this study,
papers on the four kinds of Bovis
Calculus products and relevant
Chinese patent medicines were searched from Web of
Science,
PubMed, and
China National
Knowledge Infrastructure(CNKI). CiteSpace, citexs AI, and CNKI were employed for
bibliometric analysis and
knowledge map
analysis. On this basis, the status, trend, and focuses of
research on Bovis
Calculus and relevant
Chinese patent medicines were summarized. The results suggested overall slow development in the
research on Bovis
Calculus and relevant
Chinese patent medicines with three typical
growth stages. It is consistent with the development of Bovis
Calculus substitutes and the national
policy for the development of
traditional Chinese medicine. At the moment, the
research on Bovis
Calculus and relevant
Chinese patent medicines has been on the rise. In recent years, there has been an
explosion of
research on them, particularly the
quality control of Bovis
Calculus and the
Chinese patent medicines, the pharmacological
efficacy of
Chinese patent medicines, such as Angong Niuhuang Pills, and the comparison of the quality of various Bovis
Calculus products. However, there is a paucity of
research on the pharmacological
efficacy and the mechanism of Bovis
Calculus. This medicinal and the relevant
Chinese patent medicines have been studied from diverse perspectives and
China becomes outstanding in this
research field. However, it is still necessary to reveal the chemical composition, pharmacological
efficacy, and mechanism through multi-dimensional deep
research.