Objective To investigate the expression of MAD2L1 in
lung adenocarcinoma and its effect on the
prognosis and immune microenvironment of
patients.
Methods The difference of MAD2L1 expression in
lung adenocarcinoma tissue and normal
lung tissue was analyzed by TCGA and GEO database.
Survival analysis was carried out to evaluate the prognostic significance of MAD2L1
gene expression in
lung adenocarcinoma patients. StarBase database was used to construct
miRNA-MAD2L1 regulatory network of
lung adenocarcinoma. The relation between the expression of MAD2L1 and immune
cell infiltration in
lung adenocarcinoma was analyzed by TIMER database. Results The expression of MAD2L1 was up-regulated in
lung adenocarcinoma, and the high expression of MAD2L1 was significantly correlated with pathological stage and
lymph node metastasis of
lung adenocarcinoma. The
patients with high expression of MAD2L1 had a poor
prognosis. miR-101-3p/MAD2L1 axis was identified as the most potential
upstream regulation pathway of MAD2L1 in
lung adenocarcinoma. The expression level of MAD2L1 was significantly correlated with
tumor immune
cell infiltration and immune checkpoint expression. Conclusions MAD2L1 is highly expressed in
lung adenocarcinoma, which is related to poor
prognosis and
tumor immune infiltration. MAD2L1 can be used as a potential target for the
treatment of
lung adenocarcinoma.