Objective To investigate the clinical characteristics,
treatment and
prognosis of the eighth edition of AJCC stage Ⅲ
gallbladder cancer (GBC).
Methods We collected the clinical data and follow-up results of 3485
patients with AJCC 8th stage Ⅲ
gallbladder cancer.
Kaplan Meier survival curves of ⅢA and ⅢB, T3N0M0 (ⅢA), T1-2N1M0 (ⅢB) and T3N1M0 (ⅢB) were drawn and compared. Single
factor analysis and Cox multiple factor
regression analysis were used to analyze the relation between clinical characteristics,
treatment plan, stage Ⅲ subtype and
prognosis. Results One-year
survival rate of stage ⅢB
gallbladder cancer patients was 49.70%, higher than those of stage ⅢA(36.41%); the 1-year
survival rate of stage T1-2N1M0 (ⅢB)
gallbladder cancer patients was 65.52%, higher than those of stage T3N0M0 (ⅢA) (36.41%) and stage T3N1M0 (ⅢB) (37.05%). According to Cox
multivariate analysis, age,
tumor grade,
tumor size, operation mode,
radiotherapy,
chemotherapy, AJCC 8th TNM specific subtype and T stage were independent related factors affecting the
prognosis of stage Ⅲ GBC
patients (P < 0.01). Conclusion The overall
survival of stage ⅢB GBC is better than that of stage ⅢA. The
risk of stage Ⅲ GBC
death was T1-2N1M0 (ⅢB) < T3N0M0 (ⅢA) < T3N1M0 (ⅢB). Radical
cholecystectomy (number of dissected
lymph node≥6),
radiotherapy and
chemotherapy are beneficial to the improvement of
prognosis of stage Ⅲ GBC
patients.