Osteosarcoma (OS) is the most common primary malignant
bone tumor in clinic. It has high
mortality and disability rate. Effective
neoadjuvant chemotherapy combined with
limb salvage surgery can improve the 5-year
survival rate of OS
patients.
Drug resistance or low
sensitivity of
tumor cells is the most common cause of postoperative local
recurrence and
metastasis. Therefore, the
sensitivity of OS
cells to
chemotherapy drugs is of great value to the
prognosis of the
patients. In recent years,
traditional Chinese medicine has been widely used because of high
efficiency and low
toxicity. A large number of studies have confirmed that part of
traditional Chinese medicine can reverse the
chemotherapy resistance of OS
cells by regulating the ABC transmembrane
transport protein system. This article gives an overview of its related mechanisms and latest developments.