Anti-inflammatory effects of Houttuynia cordata supercritical extract in carrageenan-air pouch inflammation model / 한국실험동물학회지
Dajeong KIM; Dongsun PARK; Jangbeen KYUNG; Yun-Hui YANG; Ehn-Kyoung CHOI; Yoon-Bok LEE; Hyun-Kyu KIM; Bang-Yeon HWANG; Yun-Bae KIM.
Laboratory Animal Research
; : 137-140, 2012.
Artículo
en Inglés
| WPRIM | ID: wpr-98976
Anti-inflammatory effects of Houttuynia cordata supercritical extract (HSE) were investigated in rat carrageenan-air pouch model. Oral administration of HSE (50-200 mg/kg) suppressed carrageenan-induced exudation and albumin leakage, as well as inflammatory cell infiltration at a high dose (200 mg/kg). Intraperitoneal injection of dexamethasone (2 mg/kg) only decreased exudation and cell infiltration, while indomethacin (2 mg/kg, i.p.) reduced exudate volume and albumin content without influence on the cell number. HSE lowered tumor-necrosis factor-alpha (TNF-alpha) and nitric oxide (NO), as well as prostaglandin E2 (PGE2). Dexamethasone only reduced TNF-alpha and NO, while indomethacin decreased PGE2. The results indicate that HSE exhibits anti-inflammatory effects by inhibiting both TNF-alpha-NO and cyclooxygenase-2-PGE2 pathways.
Biblioteca responsable:
WPRO
Texto completo
Documentos relacionados