Infectious
bone defect is
bone defect with
infection or as a result of
treatment of
bone infection. It requires surgical intervention, and the
treatment processes are complex and long, which include
bone infection control,
bone defect repair and even complex soft
tissue reconstructions in some cases. Failure to achieve the
goals in any step may
lead to the failure of the overall
treatment. Therefore, infectious
bone defect has been a worldwide challenge in the field of
orthopedics. Conventionally, sequestrectomy,
bone grafting,
bone transport, and systemic/local
antibiotic treatment are standard
therapies. Radical
debridement remains one of the cornerstones for the management of
bone infection. However, the scale of
debridement and the timing and
method of
bone defect reconstruction remain controversial. With the clinical application of induced
membrane technique, effective
infection control and rapid
bone reconstruction have been achieved in the management of infectious
bone defect. The induced
membrane technique has attracted more interests and
attention, but the lack of
understanding the basic principles of
infection control and technical details may hamper the clinical outcomes of induced
membrane technique and
complications can possibly occur. Therefore, the
Chinese Orthopedic
Association organized domestic orthopedic experts to formulate An evidence-based clinical
guideline for the
treatment of infectious
bone defect with induced
membrane technique ( version 2023) according to the evidence-based
method and put forward recommendations on infectious
bone defect from the aspects of precise
diagnosis, preoperative evaluation, operation
procedure, postoperative management and
rehabilitation, so as to provide useful references for the
treatment of infectious
bone defect with induced
membrane technique.