Compared with the sham operation group, the retinal morphology of rats in the high intraocular pressure model group and the curcumintreatment group was disorganized, the number of RGCs was reduced, the GCL was thinner, the apoptosis rate of RGCs and retinalcells increased, and the expression levels of GCLM and HO-1 increased. Compared with the high intraocular pressure model group, the retinal morphology of rats in the curcumintreatment group was basically normal, the number of RGCs increased, the GCL thickened, the apoptosis rate of RGCs and retinalcells decreased, and the expression levels of GCLM and HO-1 increased.