ABSTRACT
The aim of this paper is to descibe the pathogenic mechanisms that could explain the relationship between periodontitis and adverse pregnancy outcomes, and to review the evidence from systematic reviews and interventional studies, regarding the association between the clinical indicators of periodontitis and the incidence of low birth weight or preterm births. Preterm birth and low birth weight are world wide leading perinatal problems and have evident public health implications, due to the fact that their incidence doesn't decrease in spite of the many attempts at their prevention. Both intrauterus infections and bacterial vaginosis of the mother are well known risk factors, but distant infections, even subclinicals, may also produce preterm births. Periodontitis is a chronic infection by anaerobic gram-negative organisms and may produce local and systemic infection, so a possible association between periodontitis and adverse pregnancy outcomes has been suggested. Since 1996, a number of studies have investigated the potential relationship between periodontitis and preterm and low birth weight. However, results have been controversial and more research is needed in order to confirm or discard this association.
Subject(s)
Infant, Low Birth Weight , Periodontitis/epidemiology , Pregnancy Complications/epidemiology , Premature Birth/epidemiology , Premature Birth/etiology , Female , Humans , Infant, Newborn , PregnancyABSTRACT
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The aim of this paper is to descibe the pathogenic mechanisms that could explain the relationship between periodontitis and adverse pregnancy outcomes, and to review the evidence from systematic reviews and interventional studies, regarding the association between the clinical indicators of periodontitis and the incidence of low birth weight or preterm births.Preterm birth and low birth weight are world wide leading perinatal problems and have evident public health implications, due to the fact that their incidence doesnt decrease in spite of the many attempts at their prevention. Both intrauterus infections and bacterial vaginosis of the mother are well known risk factors, but distant infections, even subclinicals, may also produce preterm births. Periodontitis is a chronic infection by anaerobic gram-negative organisms and may produce local and systemic infection, so a possible association between periodontitis and adversepregnancy outcomes has been suggested.Since 1996, a number of studies have investigated the potential relationship between periodontitis and preterm and low birth weight. However, results have been controversial and more research is needed in order to confirm or discard this association (AU)
Subject(s)
Humans , Female , Pregnancy , Periodontitis/epidemiology , Obstetric Labor, Premature/epidemiology , Periodontitis/complications , Pregnant Women , Infant, Low Birth WeightABSTRACT
AIM: The aim of this secondary analysis is to explore whether the application of different definition criteria of periodontitis, used in other similar studies, has an influence on the significance of the association between periodontitis and prematurity or low birth weight. MATERIAL AND METHODS: Fourteen periodontitis definitions and more than 50 periodontal disease continuous measurements, found in 23 published studies, were applied to a cohort study that included 1296 pregnant women. The associations with adverse pregnancy outcomes were analysed using logistic regression analysis. RESULTS: Six of the 14 tested definitions of periodontitis resulted in statistically significant adjusted odds ratios (ORs) for some of the adverse pregnancy outcomes, while no significance was found for the other eight case definitions. Out of more than 50 periodontal continuous measurements tested, only 17 demonstrated statistically significant ORs. CONCLUSIONS: Our results support the hypothesis that the significance of the association between periodontal disease and pregnancy outcomes may be determined by the periodontal disease definition or measurement used.
Subject(s)
Infant, Low Birth Weight , Periodontitis/classification , Periodontitis/complications , Premature Birth/etiology , Terminology as Topic , Adolescent , Adult , Cohort Studies , Female , Humans , Infant, Newborn , Logistic Models , Odds Ratio , Periodontitis/diagnosis , Pregnancy , Risk Factors , Statistics, Nonparametric , Surveys and QuestionnairesABSTRACT
AIM: The aim of this study was to determine the association between periodontitis and the incidence of preterm birth (PB), low birth weight (LBW) and preterm low birth weight (PLBW) MATERIAL AND METHODS: One thousand and ninety-six women were enrolled. Periodontal data, pregnancy outcome variables and information on other factors that may influence adverse pregnancy outcomes were collected. Data were analysed using a logistic regression model. RESULTS: The incidence of PB and LBW was 6.6% and 6.0%, respectively. The incidence of PLBW was 3.3%. PB was related to mother's age, systemic diseases, onset of prenatal care, previous PBs, complications of pregnancy, type of delivery, the presence of untreated caries and the presence of periodontitis (odds ratio 1.77, 95% confidence interval: 1.08-2.88). LBW was related to mother's smoking habits, ethnicity, systemic diseases, previous LBW babies, complications of pregnancy and type of delivery. PLBW was related to mother's age, onset of prenatal care, systemic diseases, previous LBW babies, complications of pregnancy and type of delivery. CONCLUSIONS: The factors involved in many cases of adverse pregnancy outcomes have still not being identified, although systemic infections may play a role. This study found a modest association between periodontitis and PB. Further research is required to establish whether periodontitis is a risk factor for PB and/or LBW.
