ABSTRACT
The purpose of this research was to investigate the possible variations to the pharmacokinetics of nimesulide by the effect of age using an animal model. An experimental, analytical, prospective and longitudinal study in five dogs, from birth to 730 days of age was carried out. Nimesulide blood levels were measured in different months; concentrations were determined by HPLC-UV. Pharmacokinetic parameters were calculated by using the WinNonlin software. There were statistically significant differences (p <0.05) in most of the pharmacokinetic parameters between study of 6 months against the other three studies in different ages. Changes in the pharmacokinetic parameters of nimesulide as a result of age, are determined by the growing and maturation of the animals. Resulting data suggest that nimesulide can be used safely as a long-term analgesic in dogs, but, the dosing regimens in humans should be different when administered at early age.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/pharmacokinetics , Sulfonamides/pharmacokinetics , Animals , Dogs , Longitudinal Studies , Male , Prospective StudiesABSTRACT
El angiosarcoma radioinducido de mama es una patología poco frecuente que se da en pacientes sometidas a radioterapia después de un proceso tumoral maligno tratado con cirugía, ya sea radical con mastectomía o conservadora. Presentamos 2 casos con diferentes características. El primero corresponde a una paciente joven sometida a cirugía conservadora, radioterapia y reconstrucción, y el segundo una paciente de edad avanzada con desarrollo de angiosarcoma sobre lecho de radioterapia preoperatoria y mastectomía. En ambos casos detallamos la actitud quirúrgica llevada a cabo de forma conjunta por los Servicios de Cirugía Plástica y Cirugía General y el tratamiento adyuvante por parte del Servicio de Oncología (AU)
Radiation-induced breast angiosarcoma is a rare disease which occurs in patients submitted to radiotherapy after a malignant tumour treated with conservative surgery or mastectomy. We report 2 cases with different characteristics. The first one is a young patient with conservative surgery, radiotherapy and reconstruction. The second case is an old patient who developed an angiosarcoma after preoperatory radiotherapy and mastectomy. In both cases, the surgical attitude by the Plastic Surgery and General Surgery is detailed, and the adjuvant treatment by Oncology (AU)
Subject(s)
Humans , Female , Hemangiosarcoma/etiology , Neoplasms, Radiation-Induced/surgery , Breast Neoplasms/surgery , Mammaplasty/methods , Radiotherapy/adverse effects , Mastectomy, SegmentalABSTRACT
No disponible
Subject(s)
Humans , Male , Adolescent , Propofol/adverse effects , Delusions/chemically induced , Endoscopy, Gastrointestinal , Conduct Disorder/chemically inducedABSTRACT
The growing volume of information and introduction of new technologies in the Internal Medicine hospital department mare making the traditional updating «methods¼ of knowledge and organization obsolete. The development of new tools could help the management of information and organization of the medical departments is outdated. Electronic calendar such as the Google calendar facilitate adequate coordination among health care professionals. Our experience suggests that the Google calendar is a simple and useful tool that helps planning and organization of the clinical, educational, and research activities of the different medical departments, limits loss of information and improves efficacy with a close to zero cost of infrastructure.
Subject(s)
Hospital Departments/organization & administration , Information Management , Internal Medicine , Internet , Time FactorsABSTRACT
El volumen creciente de información y la introducción de las nuevas tecnologías en los servicios hospitalarios de Medicina Interna hacen que los «métodos» tradicionales de actualización de conocimientos y organización se hayan quedado obsoletos. El desarrollo de nuevas herramientas podría ayudar en la gestión de la información y organización de los servicios médicos. Los calendarios electrónicos como el Google calendar facilitan la coordinación de los profesionales de la salud. Nuestra experiencia sugiere que Google calendar es una herramienta que facilita la organización de la actividad asistencial, docente y de investigación de los servicios médicos, limita la pérdida de información, y mejora su eficiencia con un coste de infraestructura prácticamente nulo(AU)
The growing volume of information and introduction of new technologies in the Internal Medicine hospital department mare making the traditional updating «methods» of knowledge and organization obsolete. The development of new tools could help the management of information and organization of the medical departments is outdated. Electronic calendars such as the Google calendar facilitate adequate coordination among health care professionals. Our experience suggests that the Google calendar·is a simple and useful tool that helps planning and organization of the clinical, educational, and research activities of the different medical departments, limits loss of information and improves efficacy with a close to zero cost of infrastructure(AU)
