ABSTRACT
PURPOSE: Time to initiation and completion of adjuvant therapy are critical to improve postoperative oncologic outcomes. This study aims to determine whether an Enhanced Recovery After Surgery (ERAS) pathway for gastric cancer surgery promotes early Return to Intended Oncologic Therapy (RIOT). METHODS: This is a before-after intervention study including patients with gastric adenocarcinoma who underwent surgery from January 2016 to January 2021. Two periods were denoted based upon the implementation date of our institutional ERAS pathway (June 2018). Our primary outcome was time to RIOT after surgery. Hodges-Lehmann analysis was used to estimate median differences of non-parametric outcomes. RESULTS: Seventy patients with gastric adenocarcinoma were included (35 in pre-ERAS period and 35 in post-ERAS period). Fourteen of the pre-ERAS and twenty-two patients of the post-ERAS period received adjuvant therapy. Time to RIOT was reduced in the post-ERAS period (median 39 days, IQR 31-49) by 12 days (95% CI 3-14 days, p = 0.01) compared to the pre-ERAS period (median 51 days, IQR 42-62). Length of hospital stay (LOS) was lower in the ERAS group (6 days, IQR 5-11 vs 10 days, IQR 8-13, p < 0.01). CONCLUSION: Our institutional ERAS pathway for gastric cancer surgery was associated with earlier RIOT and shorter LOS.
Subject(s)
Adenocarcinoma , Digestive System Surgical Procedures , Enhanced Recovery After Surgery , Stomach Neoplasms , Adenocarcinoma/surgery , Humans , Length of Stay , Postoperative Complications , Stomach Neoplasms/surgeryABSTRACT
Acinar cell carcinoma is an uncommon tumour, representing only 1% to 2% of all exocrine pancreatic tumours. Pancreatic-type acinar cell carcinoma can occur in other organs, including the stomach, but it is extraordinarily rare. We report a case of a 51-year-old woman with a pancreatic-type pure acinar carcinoma of the stomach coexisting with a large cell B lymphoma synchronously, and a literature review of gastric carcinomas with pancreatic cell differentiation. At present there is a preoperative underdiagnosis of these tumours that could be minimized by including this entity in the differential diagnosis of gastric cancer and by performing immunohistochemical analysis with neuroendocrine markers and exocrine pancreatic enzymes.
Subject(s)
Carcinoma, Acinar Cell , Pancreatic Neoplasms , Stomach Neoplasms , Carcinoma, Acinar Cell/diagnosis , Carcinoma, Acinar Cell/pathology , Female , Humans , Immunohistochemistry , Middle Aged , Pancreatic Neoplasms/diagnosis , Pancreatic Neoplasms/pathology , Stomach Neoplasms/diagnosis , Stomach Neoplasms/pathology , Pancreatic NeoplasmsSubject(s)
Stomach/abnormalities , Choristoma/complications , Choristoma/pathology , Cysts/congenital , Diagnosis, Differential , Digestive System Abnormalities/diagnosis , Gastrointestinal Stromal Tumors/diagnosis , Humans , Male , Middle Aged , Respiratory Mucosa , Stomach Diseases/complications , Stomach Diseases/pathologyABSTRACT
Todani proposed the most accepted classification for cystic lesions of the bile duct, including 5 types. Serena described another one, type VI, which includes cystic lesions of the isolated cystic duct, of which there are less than twenty reported cases. They differ from type II in terms of the distal cystic caliber, which is normal in type VI, and in the diagnosis which is performed intra-operatively in most of the cases. Neoplastic degeneration has an incidence of 10 to 30% in all these lesions, which is the reason why the most widely accepted treatment is cholecystectomy with resection of the cystic duct cyst dilatation and preservation of the main bile duct by a laparoscopic approach.
Subject(s)
Choledochal Cyst/diagnostic imaging , Cystic Duct/diagnostic imaging , Magnetic Resonance Imaging , Choledochal Cyst/pathology , Cystic Duct/pathology , Female , Humans , Middle AgedABSTRACT
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