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Cardiovasc J Afr ; 27(4): 242-245, 2016.
Article in English | MEDLINE | ID: mdl-27841912

ABSTRACT

AIM: To investigate and compare uncoated and phosphorylcholine-coated oxygenators in terms of induction of humoral immune response during coronary artery bypass surgery. METHODS: A total of 20 consecutive patients who underwent coronary artery bypass surgery were randomly distributed into two groups according to the type of oxygenator used during surgery. Group 1 consisted of 10 patients who were operated on using phosphorylcholine-coated oxygenators. Group 2 contained 10 patients who underwent surgery using uncoated oxygenators. Blood and oxygenator fibre samples were obtained and compared in terms of immunoglobulins (IgG, IgM), complements (C3c, C4), serum total protein and albumin levels using electron microscopy and flow cytometry. RESULTS: In group 1, levels of IgM, IgG, total protein and serum albumin were significantly increased at the end of cardiopulmonary bypass (CPB) compared to those at the beginning of CPB. In group 2, C3c and C4 levels at the beginning of CPB were found to be significantly higher than at the end. Electron microscopic examination of oxygenator fibres demonstrated that phosphorylcholine-coated fibres were less likely to be adsorbed by serum proteins and complements than the uncoated fibres. CONCLUSION: Our results indicate that phosphorylcholine-coated oxygenators seemed to induce humoral immune response to a lesser extent than uncoated oxygenators during coronary artery bypass procedures.


Subject(s)
Cardiopulmonary Bypass/instrumentation , Coated Materials, Biocompatible , Coronary Artery Bypass , Immunity, Humoral , Oxygenators, Membrane , Phosphorylcholine/immunology , Adsorption , Aged , Biomarkers/blood , Cardiopulmonary Bypass/adverse effects , Coated Materials, Biocompatible/adverse effects , Complement C3c/metabolism , Complement C4/metabolism , Coronary Artery Bypass/adverse effects , Cross-Sectional Studies , Equipment Design , Female , Flow Cytometry , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Microscopy, Electron , Middle Aged , Oxygenators, Membrane/adverse effects , Phosphorylcholine/adverse effects , Phosphorylcholine/metabolism , Serum Albumin/metabolism , Serum Albumin, Human , Surface Properties , Treatment Outcome , Turkey
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