ABSTRACT
OBJECTIVE: Panic disorder (PD) is now recognized as a common and important problem in children, and particularly adolescents, and one that can negatively affect daily well-being and educational performance. The aim of this study was to investigate the relationship between heart rate variability (HRV) and the severity of symptoms before and after treatment with psychotherapy and fluoxetine. METHODS: The PD study group consisted of 23 children diagnosed with PD and the healthy control (HC) group comprised 27 healthy children. Panic-anxiety symptoms were measured using 2 assessments performed before and after treatment. HRV was evaluated with a 24-hour Holter examination. RESULTS: According to the analysis of the 24-hour, all-day Holter device recordings, the high frequency (HF) and parasympathetic (%) scores in the PD group were lower than those of the HC group (p<0.05). The low frequency (LF)/HF ratio and sympathetic (%) scores in the PD group were higher than those of the HC group (p<0.05). The analysis of daytime readings indicated that the HF values of the PD group were lower than those of the HC group (p<0.05), while the very LF/HF ratio and LF/HF ratio were higher than those of the HC group (p<0.05). Analysis of nighttime Holter results revealed that the rMSSD, pNN50, and HF readings of the PD group were lower than those of the HC group (p<0.05), while the LF/HF ratio in PD patients was higher than that seen in the HC group (p<0.05). CONCLUSION: In children and adolescents with PD, increased sympathetic activity can cause changes in some HRV parameters. Some of these changes may return to normal with treatment.
Subject(s)
Anti-Anxiety Agents/therapeutic use , Fluoxetine/therapeutic use , Heart Rate/physiology , Panic Disorder , Psychotherapy , Adolescent , Case-Control Studies , Child , Electrocardiography, Ambulatory , Humans , Panic Disorder/diagnosis , Panic Disorder/epidemiology , Panic Disorder/physiopathology , Panic Disorder/therapy , Severity of Illness Index , Treatment Outcome , TurkeyABSTRACT
Akut bakteriyel menenjit ve santral sinir sistemi sant enfeksiyonlarinda etkenler ve antibiyotik duyarliliklari
Subject(s)
Anti-Infective Agents/pharmacology , Cerebrospinal Fluid Shunts/adverse effects , Gram-Negative Bacteria/drug effects , Gram-Positive Bacteria/drug effects , Meningitis, Bacterial/microbiology , Adolescent , Adult , Aged , Aged, 80 and over , Cerebrospinal Fluid/microbiology , Child , Child, Preschool , Female , Gram-Negative Bacteria/isolation & purification , Gram-Positive Bacteria/isolation & purification , Humans , Infant , Male , Meningitis, Bacterial/etiology , Microbial Sensitivity Tests , Middle Aged , Prospective StudiesABSTRACT
In this study, bactericidal activity of widely used disinfectants and antiseptics (glutaraldehyde, laurylbispropylidentriamin 5 g and benzalkoniumchlorid 20 g, polyvinylpyrolidon iodine, benzalkonium chloride and sodium hypochloride) against some nosocomial bacterial isolates were investigated by qualitative and quantitative suspension test methods. One methicillin-resistant Staphylococcus aureus (MRSA), 6 multi drug-resistant Gram-negative hospital isolates (Escherichia coli, Pseudomonas aeruginosa, Enterobacter cloaca, Klebsiella pneumoniae, Citrobacter diversus, Serratia marcescens) and 3 standard strains of American Type Culture Collection (ATCC) bacteria (S. aureus, P. aeruginosa, E. coli) were tested against three different concentrations of disinfectants of which, manufacturer's recommended use-dilution, 1/2 and 1/4 of those recommended dilutions. All tested disinfectants were found effective in all three concentrations against nosocomial isolates in five minutes, by using both qualitative and quantitative suspension methods. When the test was repeated with albumine, bactericidal activities of disinfectants were found the same. Our findings showed that these disinfectants can be still used in safe for the sterilization in hospital, and routine disinfection protocols do not need to be alerted.
