ABSTRACT
PURPOSE: The goal of this study was to investigate the radiation dose and diagnostic efficacy of cardiac computed tomography angiography (CCTA) using prospective ECG-gated high-pitch dual-source computed tomography (DSCT) in the diagnosis of congenital cardiovascular abnormalities in pediatric population. MATERIALS AND METHODS: One hundred five pediatric patients who were clinically diagnosed with congenital heart disease with suspected extracardiac vascular abnormalities were included in the study. All CCTAs were performed on a 128×2-section DSCT scanner. CCTA findings were compared with surgical and/or conventional cardiac angiography findings. Dose-length product (DLP) and effective doses (ED) were calculated for each patient. Patients were divided into 4 groups by age, and ED and DLP values were compared among groups. The image quality was evaluated using a five-point scale. RESULTS: CCTA showed 173 abnormalities in 105 patients. There were 2 patients with false positive and 3 with false negative findings. The sensitivity and specificity of CCTA were 98.3% and 99.9%, respectively. The positive predictive value and negative predictive value of CCT were 98.9% and 99.9%, respectively. The average DLP and ED values were 15.6±9.6 (SD) mGy.cm and 0.34±0.10 (SD) mSv, respectively. The mean image quality score was 4.8±0.5 (SD) in all patients. The inter-observer agreement for the image quality scores was good (κ=0.80). CONCLUSION: CCTA is an excellent imaging modality for evaluation of cardiovascular abnormalities and provides excellent image quality with very low radiation exposure when low-dose prospective ECG-triggered high-pitch DSCT is used.
Subject(s)
Abnormalities, Multiple/diagnostic imaging , Cardiac-Gated Imaging Techniques/methods , Cardiovascular Abnormalities/diagnostic imaging , Computed Tomography Angiography/methods , Coronary Angiography/methods , Heart Defects, Congenital/diagnostic imaging , Image Processing, Computer-Assisted/methods , Adolescent , Child , Child, Preschool , Humans , Infant , Infant, Newborn , Phantoms, Imaging , Prospective Studies , Radiation Dosage , Sensitivity and SpecificityABSTRACT
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Subject(s)
Humans , Male , Female , Child , Coronary Aneurysm/metabolism , Coronary Aneurysm/pathology , Mucocutaneous Lymph Node Syndrome/diagnosis , Tomography, X-Ray Computed/methods , Tuberculosis, Lymph Node/diagnosis , Conjunctivitis/metabolism , Ultrasonography/methods , Coronary Aneurysm/complications , Coronary Aneurysm , Mucocutaneous Lymph Node Syndrome/complications , Tomography, X-Ray Computed/instrumentation , Tuberculosis, Lymph Node/complications , Conjunctivitis/pathology , Ultrasonography/instrumentationSubject(s)
B-Lymphocytes , Chromosome Disorders/complications , Chromosome Disorders/diagnosis , Heart Defects, Congenital/complications , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/genetics , Chromosome Deletion , Chromosome Disorders/genetics , Chromosomes, Human, Pair 18/genetics , Female , Heart Defects, Congenital/genetics , Humans , Infant, NewbornABSTRACT
Seckel syndrome is an autosomal recessive disease presenting with marked growth retardation, microcephalic dwarfism, some facial and skeletal abnormalities. Tricuspid atresia is a rare and life threatening cyanotic congenital heart diseases, with an incidence of 1% to 3%. It is feature of the anatomically normally related great arteries with a large ventricular septum defect and stenosis of right ventricular outflow tract. Tricuspid atresia has never been reported in patients with Seckel syndrome. Here we report a 15-day-old girl baby diagnosed as having Seckel syndrome with tricuspid atresia.
