Midwifery Students' Traumatic Childbirth Experiences, Traumatic Childbirth Perceptions, and Levels of Fear of Childbirth.

INTRODUCTION: Although childbirth is generally seen as a positive phenomenon, negative childbirth events can be experienced as well. Midwifery students are at risk of encountering traumatic events throughout their education. The primary aim of this research was to reveal midwifery students' experiences of witnessing traumatic events at childbirth. The secondary aim was to determine the effects of traumatic childbirth experiences witnessed by midwifery students on their traumatic childbirth perceptions and levels of fear of childbirth. METHODS: This cross-sectional study was conducted between January 1 and June 30, 2021. The study sample consisted of 517 midwifery students in Turkey. Data were collected using a descriptive information form, the Traumatic Childbirth Perception Scale (TCPS), and the Visual Analog Scale (VAS) for measuring fear of childbirth. RESULTS: The majority (88%) of students witnessed a traumatic event at childbirth. The mean (SD) TCPS score was 59.7 (26.1), and the level of fear of childbirth measured with VAS was 5.1 (2.7). A moderate positive correlation was found between the VAS score and TCPS scores (r = .63; P < .001). Although the mean TCPS scores of students who witnessed a traumatic event were not signficiantly different from those who did not, their mean VAS score was higher than those who did not (P = .001). Among students who experiences traumatic events at childbirth, 35.8% stated that the traumatic events negatively affected their education, and 65.6% reported that they thought it would negatively affect their future professional life. DISCUSSION: Witnessing traumatic events at childbirth is associated with increased perception of childbirth as traumatic and fear of childbirth in midwifery students. Traumatic experiences can affect midwifery students' educational and professional lives. Educators in the field of midwifery should support students in coping with traumas.

Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.

Four series of sulfonamides incorporating chromone moieties were synthesized and assessed for their cytotoxic activity against MCF-7 and A-549 cell lines, considering the fact that some of these tumors overexpress isoforms of carbonic anhydrase (CA, EC 4.2.1.1) which is inhibited by sulfonamides. Most new sulfonamides showed weak inhibitory activity against the offtarget, cytosolic isoforms hCA I, II but effectively inhibited the tumor-associated hCA IX and XII. The most active compounds featured a primary SO2NH2 group and were active in the low micromolar range against MCF-7 and A-549 cell lines. Compound 4a showed IC50 of 0.72 and 0.50 µM against MCF-7 and A-549 cell lines, respectively, and was further evaluated for its proapoptotic activity which proved enhanced in both tumor types.