Telogen effluvium after COVID-19 vaccination among public in Saudi Arabia.

Background: Number of reports linked Telogen effluvium to coronavirus disease 2019 (COVID-19) infection. However, data about Telogen effluvium after COVID-19 vaccination are limited. Objectives: To estimate prevalence of Telogen effluvium among those who received COVID-19 vaccination. Methods: A cross-sectional study was performed during July 2021. Adults who received one of recognized COVID-19 vaccine irrespective of previous COVID-19 infection were asked to fill a questionnaire. Results: The majority of participants were females (90.3%). The most common age group was between 21 and 30 years (51.9%). Out of 991 participants who were included in the current analysis, 670 (67.6%) reported post-vaccination hair fall. The probable causes of post-vaccination hair fall were vaccine-related in 185 (27.6%) participants, other causes in 326 (48.7%) participants, and unclear in 326 (48.7%) participants. Post-vaccination hair fall was significantly higher among females compared with males (68.5% versus 57.9%, P = 0.036), those who did not suffer compared with those who suffered from hair fall before vaccination (72.1% versus 63.4%, P = 0.003), and those who did not report compared with those who reported preexisting conditions that might be related to hair fall (74.5% versus 57.3%, P < 0.001). Conclusion: We are reporting a high prevalence of post-vaccination hair fall, which affected approximately two-thirds of participants who received COVID-19 vaccines. Only 28% of these participants were apparently vaccine related. The role of COVID-19 infection and stress caused by infection and vaccine cannot be excluded. Primary care physician and dermatologist need to consider the possibility of COVID-19 vaccine as a potential cause of hair loss.

1927 nm Thulium Laser Successfully Treats PostInflammatory Hyperpigmentation in Skin of Color.

BACKGROUND: Treatment of postinflammatory hyperpigmentation (PIH) in patients with dark skin is challenging as the treatment itself might provoke paradoxical PIH. Only few studies examined the safety and efficacy of nonablative laser treatment in these patients. The objective was to examine efficacy and safety of nonablative 1927 nm wavelength laser followed by bleaching creams in the treatment of PIH. METHODS: It was a prospective interventional pilot study that was conducted during 2019. All patients were of Fitzpatrick skin type IV who had unsatisfactory response to topical bleaching creams used for at least three months. Patients received one to four sessions of laser treatment (6 weeks apart) followed by topical hydroquinone 4% cream twice daily for 6 weeks. Improvement was assessed by two blinded independent dermatologist evaluators. RESULTS: A total of nine patients were enrolled and the outcome could not be assessed in one patient who was lost for follow-up. The affected sites were the abdomen, face, and other body parts. Three of the eight evaluated patients had excellent response (37.5%), four had satisfactory response (50.0%), and one had nonsatisfactory response (12.5%). The downtime was manifested as edema and erythema that disappeared after 5 to 7 days. Improvement was more evident in first session and it declined in subsequent sessions. None of the patients had paradoxical pigmentation after treatment. CONCLUSIONS: Low energy low density nonablative fractional 1927 nm wavelength laser treatment followed by topical hydroquinone 4% cream for 6 weeks is a safe and effective modality for improving PIH in patients with darker skin types.

Identifying Patients at Higher Risk of Depression Among Patients with Vitiligo at Outpatient Setting.

INTRODUCTION: Chronic skin diseases including vitiligo could have profound psychological burden. The factors influencing the expression of depression in patients with vitiligo received little attention both nationally and internationally. AIM: The aim of the current study was to estimate the burden and severity of depression and to characterize their associated sociodemographic and clinical characteristics among patients with vitiligo. METHODS: A cross-sectional survey study was conducted among patients with vitiligo of both genders attending dermatology outpatient clinics at a tertiary care hospital during 2019. Modified Beck Depression Inventory Scale was used for screening for depression. RESULTS: A total 308 patients with vitiligo have been included in the current analysis. The average age was 27±14.5 years. Approximately 59.7% of the patients were males and the majority (63.6%) were single. A total 168 (54.5%) patients had some depressive symptoms. The majority of these patients had mild depression (52.4%), followed by moderate (33.3%) and severe (14.3%) depression. Moderate and/or severe depression were significantly higher among children and adolescents (p=0.036), single patients (p=0.006), those with lower than high school education (p<0.001), those with shorter duration of the disease (p<0.001), and those using phototherapy (p=0.003). Depression burden and severity were not significantly associated with gender and lesion distribution. CONCLUSION: Sociodemographic and clinical characteristics can easily characterize the risk of depression among patients with vitiligo. The current findings may help dermatologist to pick patients at higher risk of depression early after diagnosis of vitiligo. Dermatologists should have low threshold for referring such patients to psychiatry clinics.

Q-switched double-frequency Nd:YAG (532 nm) laser is an effective treatment for racial lip pigmentation.

INTRODUCTION: Lip darkening is a relatively common condition, especially in the Middle East and Southeast Asia. It is well documented in the literature and generally considered to be multifactorial. The presentation can be physiologic or pathologic and caused by a variety of local or systemic factors. CASE PRESENTATION: A 32-year-old female with skin type IV presented to the clinic with concerns of darkening lips with no associated symptoms or history of disease. On examination, her lips were homogenously dark brown with the upper lip slightly darker than the lower lip. OBJECTIVE: To report effectivness of Q-switched 532 nm laser for treatment of lip pigmentation. METHOD: Topical 2.5% lidocaine/prilocaine (EMLA) cream was applied 30 minutes prior to laser therapy. The region was treated with Q-switched 532 nm laser (Medlite). RESULT: Two weeks after laser treatment , threre was satisfying subjective and objective improvment in lip pigmnetation. CONCLUSION: Q-Switched 532 nm laser effectively reduces lip pigmentation after one session with minimal adverse effects and lasting results.

Review of sterility of reused stored dermal filler.

OBJECTIVE: This review is primarily focusing on the legitimate concern about bacterial contamination after reuse of stored filling syringes and its associated risk of infections. METHODS: A comprehensive literature review was done through searching the PubMed, Medline, Google Scholar, and ResearchGate without setting a time limit. The following search terms were used soft tissue filler, hyaluronic acid, or calcium hydroxylapatite AND sterility, safety, retouch, touch up, or reuse. RESULT: Immediate replacing needles used in injection with a sterile substitute before storage was associated with no growth in one study (Archives of Facial Plastic Surgery, 11, 2009, 271) and growth in another study (Dermatologic Surgery, 2017, 43, 967). There was no reported infection in the only patient-based study that examined the adverse events among patients injected with stored hyaluronic acid filler syringes. CONCLUSION: All published research showed that stored fillers are safe and do not increase the risk of biofilm formation.

Perception of primary health care providers of plastic surgery and its influence on referral.

OBJECTIVES: The aim of this study is to understand the level of knowledge and awareness of plastic surgery among primary health care (PHC) providers in Qassim region, Kingdom of Saudi Arabia. METHODS: This is a cross-sectional study conducted from February 2018 to March 2018 among health care providers in PHC in Qassim region, Saudi Arabia. Overall, 82 health care providers were recruited using simple random sampling. Filling the questionnaire was considered as approval to join the study. The study included general practitioners and family medicine specialists. Other specialties working in PHC were excluded from the study. RESULTS: In total, 82 physicians were enrolled in this study. Physicians considered that out of 28 listed disorders 16 of them have chosen a plastic surgeon as the best surgeon to perform the necessary surgery. The selection of plastic surgeon as the best doctor for a specific disorder was as follows: Burn deformities (93%), liposuction (87.7%), breast reduction/enhancement (86.8%), skin grating (84.4%), surgery for facial wrinkles (79.2%), electrical burns (71.6%), Botox (64.4%), cuts over the face (63.5%), abdominoplasty (62.9%), burns (59.4%), congenital anomalies of ear and nose (51.5%), deformities of leprosy (51.4%), sex change surgery (49.2%), non-healing wound over legs (47.1%), cleft lip and palate (41.7%), and totally, amputee thumb, finger, or hand (36.1%). The selection of other disorders was distributed almost similarly. CONCLUSION: General practitioners need more orientation for plastic surgery discipline. In this study, the majority of the study physicians do not have enough knowledge about the meaning of plastic surgery. As a PHC physician, knowledge about this topic is very essential because the patient is very likely to ask about the best surgeon for referral and the potential positive and negative effect of the reconstructive procedure.

Multifocal congenital pyogenic granuloma successfully treated with oral propranolol.

Disseminated congenital pyogenic granuloma (DCPG) is an uncommon condition. Individual lesions of DCPG share clinical and histologic similarities with infantile hemangioma (IH); endothelial glucose transporter 1 (GLUT-1), which is highly expressed in IH but generally not in pyogenic granulomas (PG), is an important diagnostic tool. Treatment for DCPG remains difficult. We describe a case of DCPG effectively treated with propranolol.

Gender-specific differences in the awareness and intake of Vitamin D among adult population in Qassim Region.

BACKGROUND: Despite the abundance of sunshine throughout the year, Vitamin D deficiency is highly prevalent among different Saudi populations. The objective of the current study was to evaluate the awareness and intake of Vitamin D and their association among adults of both genders. MATERIALS AND METHODS: A cross-sectional study was done between June and August 2016 among adult patients and their family members (>18 years) presenting at 6 Primary Care Centers in the Qassim region, Saudi Arabia. RESULTS: A total of 500 study participants were included in the study; 54.6% of the participants were males and mostly aged most between 26-50 years. The majority of the participants had heard of Vitamin D (91.4%), believed in its importance for health (92.8%), were aware of the symptoms of Vitamin D deficiency (72.6%), and were able to identify exposure to sunlight (81.4%) and diet (70.4%) as sources. The sources of Vitamin D used by the participants were exposure to the sun (57.2%), Vitamin D-rich foods (51.2%) and supplements (18.8%). There was a significant association between overall awareness of Vitamin D and intake of at least 2 sources of Vitamin D in males (P < 0.001) but not females (P = 0.920). Although females had better awareness than males, exposure to the sun was much lower in females than males. CONCLUSION: As supplementation was very low in both genders, and since cultural factors that limit females' exposure to the sun are not easily modifiable, the current findings further underline the critical importance of Vitamin D supplementation, particularly in females in Saudi Arabia.

A synopsis of the history of Hansen's disease.

Leprosy is a contagious infectious disease caused by the bacillus Mycobacterium leprae. This microorganism was discovered by Dr. Gerhard Hansen, and the illness was then baptized as Hansen's disease. For a long time, Hansen's disease was thought to be hereditary-a curse or a punishment from God. The disease affects skin and nerves and can cause severe damage. Due to its destructive effects, leprosy has caused fear, segregation, and prejudice in all societies since Biblical times. Patients with Hansen's disease have not been treated humanely around the world throughout the ages. This article is a summary of curious and interesting facts about the history and cultural aspects of Hansen's disease, which has chastised humanity for centuries. These facts are about the discovery of the disease, its propagation, the evolution of treatments, and the prejudice of society towards patients.

Botulinum Toxin for the Treatment of Gummv Smile.

AIM: The aim was to evaluate the effect of botulinum toxin (Botox) injections as a conservative treatment for gummy smile. MATERIALS AND METHODS: An experimental in vivo study was conducted at a dermatology clinic in Riyadh in January 2016. The study included 23 female patients who ranged from 20 to 50 years and were treated with Botox injections due to excessive maxillary gingival display. The patients with short clinical crowns or long maxilla, those who were pregnant or breastfeeding, and patients with neuromuscular disorders were excluded. Patients received Botox type I, injected 3 mm lateral to the alar-fascial groove at the level of the nostril opening at the insertion of the levator labii superioris alaeque nasi muscle. Photos were taken of the patient's smile before and after the treatment and were then uploaded to the SketchUp program to calculate improvements in gingival display. The distance from the lower margin of the upper lip to the gingival margin was calculated pre- and posttreatment. The amount of improvement was calculated as (pre-Botox treatment - post-Botox treatment/pre-Botox treatment × 100). The mean percentage of the total improvement was analyzed. RESULTS: A total of 23 female patients received treatment to improve their gummy smile. Improvement was clear 2 weeks after Botox injection. The mean percentage of improvement in the gingival display was 99.6%. CONCLUSION: Botox type I is an effective conservative technique to improve gummy smile caused by muscular hyperfunction. CLINICAL SIGNIFICANCE: Patients' retention highly indicated that they were satisfied with the provided treatment by Botox injections. Improving the quality of life with least painful experience and immediate results was the major advantage for Botox type I.

Tranexamic Acid in the Treatment of Melasma: A Review of the Literature.

Melasma is a common acquired pigmentary disorder marked by irregular hyperpigmented macules or patches and most commonly occurs in women of darker skin color. It is a chronic often-relapsing condition that causes negative psychosocial effects in those affected. Current treatments such as hydroquinone, kojic acid, and retinoids, among others, demonstrate variable efficacy and side-effect profiles. We conducted a comprehensive literature review examining the use of tranexamic acid (TA), a well-known anti-fibrinolytic agent, in the treatment of melasma. TA delivered orally, topically, and through physical methods works via the inhibition of ultraviolet (UV)-induced plasmin activity in keratinocytes. Predefined search terms were entered into PubMed. Articles were then independently screened by two authors to include only those written in the English language and relating to human subjects with at least mild melasma. The search identified 28 articles, 15 of which met the criteria for full review. The review revealed that TA treatment for melasma is equally effective or more effective than other standard therapies and may induce fewer side effects. Our comprehensive review suggests that TA may be a promising treatment option for melasma because of its demonstrated effectiveness alone and in combination with other modalities as well as its limited side-effect profile.

Body dysmorphic disorder: history and curiosities.

Body dysmorphic disorder is a chronic psychiatric disorder characterized by excessive preoccupation with an absent or minimal physical deformity. It causes severe distress and impairs normal functioning. In the last centuries, this disorder has been mentioned in the medical literature by important mental health practitioners by different names, such as "dysmorphophobia" or "dermatologic hypochondriasis". However, not until the last century was it included among the obsessive-compulsive disorders, although its classification has changed over time.Patients with body dysmorphic disorder constantly seek cosmetic treatments in order to improve their physical appearance, which more often deteriorates their mental condition. The high prevalence of psychiatric disorders in cosmetic medical practice has led in this field of study to the new science "cosmetic psychodermatology". This paper presents a summary of important facts about body dysmorphic disorder and its description throughout the history of medicine.