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3.
Dermatitis ; 22(3): 127-40, 2011 May.
Article in English | MEDLINE | ID: mdl-21569742

ABSTRACT

Methyldibromoglutaronitrile/phenoxyethanol (Euxyl K 400) is a preservative found in both personal care products and industrial sources. Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. Issues related to patch-test preparations are also discussed.


Subject(s)
Dermatitis, Allergic Contact , Ethylene Glycols/adverse effects , Nitriles/adverse effects , Preservatives, Pharmaceutical/adverse effects , Animals , Consumer Product Safety/legislation & jurisprudence , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/epidemiology , Dermatitis, Allergic Contact/therapy , Ethylene Glycols/chemistry , Europe/epidemiology , Guinea Pigs , Humans , Nitriles/chemistry , Patch Tests , Preservatives, Pharmaceutical/chemistry , United States/epidemiology
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