1.
Chem Biodivers
; : e202302085, 2024 Apr 26.
Article
in English
| MEDLINE
| ID: mdl-38666662
ABSTRACT
In this work, a highly effective synthesis technique for obtaining aryl indazole under mild circumstances is provided, using trimethyl phosphine as a powerful reagent. The procedure shows that a wide range of substrates can be investigated, yielding various 2-aryl indazole derivatives with acceptable to exceptional yields and a wide range of functional group tolerance. Additionally, based on Inâ Silico studies tests were conducted to determine the anticancer activity Inâ Vitro for all produced compounds (3 a-3 j) against A549, HT-29 and HepG2â cell lines. Compoundsâ 3 c and 3 d, with IC50 values of 15, 53.55, 7.34, 7.10, 56.28, and 17.87 (µM) against A549, HT-29 and HepG2 respectively, showed significant anticancer activity.