Validation of Multidimensional Persian Version of the Work-Family Conflict Questionnaire among Nurses.

BACKGROUND: Several instruments have so far been developed in English language to measure the level of work-family conflict and further validation is required for non-English speakers. OBJECTIVE: To test factorial structure and construct validity of the Persian version of work-family conflict scale among Iranian nurse. METHODS: This study was conducted among 456 Iranian nurses working at public hospitals in 17 provinces from March 2015 to September 2015. We used a self-administrated questionnaire to collect information. Exploratory factor analysis was run using SPSS 21. Then, construct validity was evaluated using confirmatory factor analysis (CFA), convergent validity, and discriminant validity by AMOS 21. RESULTS: Exploratory factor analysis extracted four dimensions that explained 65.5% of the variance observed. The results of confirmatory factor analysis showed that our data fitted the hypothesized four dimensional model of work-family conflict construct. The average variance extracted was used to establish convergent and discriminant validity. CONCLUSION: The Persian version of work-family conflict questionnaire is a valid and reliable instrument among Iranian nurses.

Synthesis and Pharmacological Evaluation of New Chemical Entities from Ibuprofen as Novel Analgesic Candidates.

Non-steroidal anti-inflammatory drugs (NSAIDs) are the first choice of drugs that are normally used for the treatment of pain and inflammation. Ibuprofen (I) and its analogues as the most widely used NSAIDs have been synthesized in recent years. In an effort to establish new candidates with improved analgesic properties, derivatives (II-VII) with substituted aromatic as well as aliphatic moieties were synthesized in this experiment and evaluated in formalin test with rats. The results were compared to ibuprofen and control groups. Findings indicated that derivatives with new alkylphenyl rings (VI and VII) had some similar or more analgesic activities relative to the control and ibuprofen groups, respectively; which could be justified as to more alkyl and phenyl groups instead of p-isobutylphenyl moiety in I.

Reliability And Validity Testing Of The Healthcare Provider-Patient Communication Instrument: A Pilot Study In A Malaysian Primary Care Setting

There is a growing interest in research on satisfaction with healthcare provider (HCP) and HCP- patient communication as a measure of healthcare quality of HCP’s communication competency. However, many communication assessments were not comprehensive measures and are not entirely accurate in measuring what is supposed to be measured. This study aimed at assessing the validity and reliability of a newly developed HCP-PC instrument in a Malaysian primary care setting. The HCP-PC instrument was developed using items adapted from existing instruments as well as self-developed items. A pilot study involving 277 clients of an outpatient clinic was conducted in HKL using the proposed instrument which was distributed immediately after face to face consultation. The content validity and Cronbach alpha reliability were assessed. Factor analysis constructed 3 components, exchanging information (EI), socioemotional behaviour (SB) and communication style (CS). All items loaded on the corresponding component with factor loading ≥0.6, suggesting that all items in the respective component are measuring the same direction. PCA of the final 30 items explain 61.98% of the total variance with 6.66%, 47.18% and 8.13% explained by EI, SB and CS respectively. Component-based reliability show strong internal consistency with Cronbach alpha, αEI= 0.92, αSB= 0.96 and αCS= 0.70. The pilot study supported the instrument validity and reliability after initial tests. However, further study needs to be done to confirm its construct validity to help establish a valid and reliable HCP-PC instrument for measuring patient satisfaction with HCP-PC that can be used in primary care setting.