ABSTRACT
A 45-year-old male smoker presented with extensive non-healing ulcerations and an occluded right common femoral artery. His left forearm had contractures from a prior stroke. We describe a combined radial-tibial access revascularization strategy.
Subject(s)
Arterial Occlusive Diseases , Catheterization, Peripheral/methods , Femoral Artery , Radial Artery/surgery , Tibial Arteries/surgery , Vascular Surgical Procedures/methods , Angiography/methods , Arterial Occlusive Diseases/diagnosis , Arterial Occlusive Diseases/physiopathology , Arterial Occlusive Diseases/surgery , Femoral Artery/diagnostic imaging , Femoral Artery/pathology , Femoral Artery/surgery , Humans , Male , Middle Aged , Treatment OutcomeABSTRACT
OBJECTIVE: We describe our experience in transradial recanalization of the superficial femoral artery (SFA), and we provide a stepwise approach accounting for the patient's height and optimizing the yield of currently available devices. METHODS AND RESULTS: Fifteen patients with simple SFA disease, including 4 patients with total SFA occlusions <15 cm, were selected for stand-alone transradial recanalization. A 6F, 125-cm multipurpose guiding catheter was used to cannulate the limb of interest and support device delivery. The procedure was successful in all patients and consisted of balloon angioplasty (using 0.014â³, 200-cm shaft monorail balloons) in all patients, and orbital atherectomy in 6 patients. We illustrate the steps and challenges of the transradial approach, namely the limited support in complex disease and the limited reach of current equipment. CONCLUSION: In patients with simple SFA disease, transradial recanalization appears feasible and safe but currently limited to balloon angioplasty ± orbital atherectomy. Proximal SFA stenting may be feasible in patients <160 cm in height.
Subject(s)
Angioplasty, Balloon/methods , Atherectomy/methods , Peripheral Arterial Disease/therapy , Radial Artery , Angioplasty, Balloon/adverse effects , Angioplasty, Balloon/instrumentation , Atherectomy/adverse effects , Atherectomy/instrumentation , Constriction, Pathologic , Feasibility Studies , Female , Femoral Artery/diagnostic imaging , Femoral Artery/physiopathology , Humans , Male , Middle Aged , New Orleans , Peripheral Arterial Disease/diagnostic imaging , Peripheral Arterial Disease/physiopathology , Punctures , Time Factors , Treatment OutcomeABSTRACT
A 57-year-old man with diabetes mellitus, systemic arterial hypertension, and end-stage kidney disease came to the hospital because his arteriovenous fistula used for hemodialysis had clotted. His blood hemoglobin level was 12.8 g/dL (reference, 13.5-17.5); and serum chemistry levels were creatinine 6.7 mg/dL (0.7-1.3), sodium 132 mEq/L (136-146), potassium 4.0 mEq/L (3.5-5.1), chloride 94 mEq/L (98-106), carbon dioxide 24 mEQ/L (23-29), calcium 9.1 mg/dL (8.4-10.2), and phosphorus 9.1 mg/dL (2.7-4.5). An electrocardiogram was recorded (Figure 1).
Subject(s)
Atrial Premature Complexes/diagnosis , Catheter Obstruction , Renal Dialysis/adverse effects , Thrombosis/complications , Vascular Access Devices/adverse effects , Atrial Premature Complexes/etiology , Follow-Up Studies , Humans , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/therapy , Male , Middle Aged , Remission, Spontaneous , Renal Dialysis/methods , Thrombosis/physiopathologyABSTRACT
BACKGROUND: Calcification in atherosclerotic plaques has been viewed as a marker of plaque stability, but whether calcification accumulates in specific anatomic sites in the carotid artery is unknown. We determined the burden and distribution of calcified plaque in carotid endarterectomy (CEA) tissues. METHODS: A total of 22 CEA tissues were imaged with high-resolution micro-computed tomography (micro-CT). Total plaque burden and total calcium score using the Agatston method were quantified. The Agatston score (AS) was also normalized for tissue size. Plaque and calcium distribution were analyzed separately for three CEA regions: common segment (CS), bulb segment (BS), and internal/external segments (IES). RESULTS: The average CEA tissue length was 40.83 (interquartile range [IQR] 33.31-42.41) mm with total plaque burden of 103.45 (IQR: 78.84-156.81) mm(3) and total AS of 38.58 (IQR 11.59-89.97). Total plaque volume was 21.02 (IQR: 14.47-25.42) mm(3) in the CS, 37.89 (22.59-48.32) mm(3) in the BS, and 54.05 (36.87-74.52) mm(3) in the IES. Of the 22 tissues, 15 had no calcium in the CS compared with three in the bulb and two in the IES. Normalized calcified plaque was most prevalent in the BS, the IES and was least prevalent in the CS. The overall correlation of calcification between histology sections and matched micro-CT images was 0.86 (p<0.001). CONCLUSIONS: Calcified plaque is heterogeneously distributed in CEA tissues with most in the bulb and IES regions. The amount of calcification in micro-CT slices shows a high correlation with matched histology sections.
Subject(s)
Calcinosis/diagnostic imaging , Calcinosis/pathology , Carotid Stenosis/diagnostic imaging , Carotid Stenosis/pathology , Biopsy, Needle , Carotid Stenosis/surgery , Cohort Studies , Endarterectomy, Carotid/methods , Female , Humans , Image Processing, Computer-Assisted , Immunohistochemistry , Male , Observer Variation , Plaque, Atherosclerotic/diagnostic imaging , Plaque, Atherosclerotic/pathology , Sensitivity and Specificity , Severity of Illness Index , Tissue Culture Techniques , X-Ray Microtomography/methodsABSTRACT
INTRODUCTION: The aim of the study was to investigate the prevalence and risk factors of muscle complications among patients using statins. METHODS: We conducted a prospective comparative study on 345 patients receiving statins and compared the findings with an age- and gender-matched control group of 85 subjects. Univariate and multivariate analyses with logistic regression models were used to study the association of different patient and disease characteristics with muscle complications. RESULTS: Adverse reactions were reported by 21% of patients and 5.9% of controls (P = 0.0013). Objective weakness was found in 15% of the patients who reported muscle symptoms (3.2% of the total cohort), but not in controls. Older age, longer duration of statin use, diabetes, stroke, and lower body mass index were associated with increased risk of developing these symptoms. CONCLUSIONS: Adverse reactions to statins may be more common than previously reported, and they may be affected by specific patient and disease characteristics.
