ABSTRACT
This study was conducted to assess genetic associations with endometriosis in a Puerto Rican population. Statistically significant differences in the allelic frequencies and genotype distribution of genetic variants in lysyl oxidase-like protein 4 (LOXL4) and complement component 3 (C3) were documented in patients with endometriosis-associated infertility versus controls, and in patients with endometriosis versus controls, respectively. In women who have the risk genotype at both single-nucleotide polymorphisms, the estimated risk for endometriosis nearly doubled.
Subject(s)
Amino Acid Oxidoreductases/genetics , Complement C3/genetics , Endometriosis/genetics , Infertility, Female/genetics , Polymorphism, Single Nucleotide , Adult , Case-Control Studies , Chi-Square Distribution , Endometriosis/complications , Endometriosis/enzymology , Endometriosis/immunology , Female , Gene Frequency , Genetic Predisposition to Disease , Humans , Infertility, Female/enzymology , Infertility, Female/immunology , Linkage Disequilibrium , Odds Ratio , Phenotype , Protein-Lysine 6-Oxidase , Puerto Rico , Risk Assessment , Risk FactorsABSTRACT
The objective of this study was to assess the burden of endometriosis by obtaining patient-reported outcome data describing the experience of living with this disease. Survey data from 107 women with self-reported, surgically diagnosed endometriosis showed that living with this disease may be characterized by physical limitations that disrupt health, work, and daily life.
Subject(s)
Activities of Daily Living , Endometriosis/complications , Health , Uterine Diseases/complications , Work , Activities of Daily Living/psychology , Adult , Case-Control Studies , Cost of Illness , Endometriosis/epidemiology , Endometriosis/physiopathology , Endometriosis/psychology , Female , Health Records, Personal , Humans , Infertility, Female/etiology , Infertility, Female/psychology , Middle Aged , Pelvic Pain/etiology , Pelvic Pain/psychology , Quality of Life , Self Concept , Surveys and Questionnaires , Task Performance and Analysis , Uterine Diseases/epidemiology , Uterine Diseases/physiopathology , Uterine Diseases/psychology , Women's Health , Work/physiology , Work/psychologyABSTRACT
OBJECTIVE: To determine the prevalence of endometriosis and its symptoms in a Puerto Rican cohort, and to describe the menstrual, obstetric, and clinical profiles of the women. METHODS: A self-administered questionnaire was given to 1285 Puerto Rican women. Categorical variables were compared using chi2 analysis or Fisher exact test. RESULTS: There were 57 self-reported cases of endometriosis (48 surgically confirmed) among 1193 valid questionnaires, for a point prevalence of 4.0%. A diagnosis of endometriosis was significantly associated with dysmenorrhea, dyspareunia, and chronic pelvic pain, but not with menstrual cycle characteristics. Undiagnosed women commonly reported signs and symptoms of endometriosis. CONCLUSIONS: The estimated prevalence of endometriosis in Puerto Rico is 4.0%, comparable to what has been reported in other populations. Endometriosis symptoms were common in the population surveyed, indicating the need for increased awareness and development of public health policies leading to early diagnosis and appropriate management.
