ABSTRACT
Skin necrosis from intravenous infiltration of soft tissue is a rare but potentially devastating complication of intravenous therapy. Vinca alkaloids are among the intravenous drugs with the highest destructive power. We report two cases of skin necrosis from accidental extravasation of vinorelbine, a semisynthetic analogue of vinblastine, rarely described as being responsible for this event. Histopathologic study showed separation of the dermis from necrotic epidermis, associated with cytologic atypia, in both patients, and focal necrosis of eccrine glands in one of them. We consider that intravenous infusions of vinorelbine should be performed using the preventive measures and care applied for other chemotherapeutic agents with high potential for induction of skin necrosis due to extravasation.
Subject(s)
Antineoplastic Agents, Phytogenic/adverse effects , Infusions, Intravenous/adverse effects , Skin/drug effects , Vinblastine/analogs & derivatives , Vinblastine/adverse effects , Aged , Breast Neoplasms/pathology , Carcinoma, Non-Small-Cell Lung/drug therapy , Extravasation of Diagnostic and Therapeutic Materials , Female , Forearm , Humans , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Male , Middle Aged , Necrosis , Vinblastine/administration & dosage , VinorelbineSubject(s)
Allergens/adverse effects , Cyanamide/adverse effects , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Exfoliative/diagnosis , Alcoholism/drug therapy , Dermatitis, Allergic Contact/etiology , Dermatitis, Exfoliative/etiology , Diagnosis, Differential , Humans , Male , Middle Aged , Patch TestsABSTRACT
The term HIV-associated eosinophilic folliculitis (EF) designates an idiopathic dermatitis that appears in HIV-infected patients with different clinical manifestations but with a distinctive histological feature characterized by a predominantly eosinophilic infiltrate in the follicular infundibula. On the other side, follicular mucinosis (FM) is a reaction pattern in the follicular epithelium, characterized by a mucinous degeneration of the outer sheath of follicles and sebaceous glands. It has been described in association with a variety of unrelated conditions. We report 2 HIV-infected patients with a pruritic papular eruption. Histopathological study revealed the coexistence of EF and FM. To our knowledge, this is the first report that describes this association. The possible relationship between these two entities is discussed.
Subject(s)
Eosinophilia/complications , Folliculitis/complications , HIV Infections/complications , Mucinosis, Follicular/complications , Adult , Eosinophilia/pathology , Eosinophilia/virology , Folliculitis/pathology , Folliculitis/virology , Homosexuality, Male , Humans , Male , Mucinosis, Follicular/pathology , Mucinosis, Follicular/virology , Skin/pathology , Skin/virologySubject(s)
Leishmaniasis, Cutaneous/complications , Mucinosis, Follicular/etiology , Antiprotozoal Agents/administration & dosage , Biopsy, Needle , Disease-Free Survival , Female , Humans , Leishmaniasis, Cutaneous/drug therapy , Leishmaniasis, Cutaneous/pathology , Meglumine/administration & dosage , Meglumine Antimoniate , Middle Aged , Mucinosis, Follicular/pathology , Organometallic Compounds/administration & dosageABSTRACT
We describe the case of a 10-year-old boy with a porokeratotic eccrine ostial and dermal duct nevus (PEODDN) of late onset. The patient had an 8-year history of multiple keratotic papules on the dorsal surface, and multiple yellowish pitting lesions on the plantar surface of the right foot. Light-microscopic studies of both lesions showed multiple cornoid lamella-like parakeratotic columns, which exclusively arose over eccrine sweat ducts in which the acrosyringium was dilated. Although PEODDN is considered to be a congenital hamartoma of eccrine origin, a review of the literature showed us that the frequency of a late-onset variant may be as high as 26%.
