1.
Lancet
; 1(8024): 1225-8, 1977 Jun 11.
Article
in English
| MEDLINE
| ID: mdl-68328
ABSTRACT
The effect of low-molecular-weight cell constituents from regenerating liver and granulation tissue on the growth of the connective tissue during skin wound healing has been investigated. Repeated injections (intravenous or subcutaneous) of these compounds greatly accelerated the growth of connective tissue by stimulation of both fibroblast proliferation and collagen biogenesis and thus promoted wound healing. These results suggest that the low-molecular-weight cell constituents from dividing cells contain internal factor(s) capable of committing resting cells to D.N.A. synthesis and division or of accelerating D.N.A. synthesis in committed cells.
Subject(s)
Cell Division , Connective Tissue/metabolism , Wound Healing , Animals , Collagen/biosynthesis , DNA/biosynthesis , Fibroblasts/metabolism , Glycosaminoglycans/metabolism , Granulation Tissue/metabolism , Liver/metabolism , Liver Regeneration , Male , Molecular Weight , Rats , Skin/injuries , Tissue Extracts , Wounds and Injuries/metabolism
2.
Mol Biol Rep
; 2(2): 151-7, 1975 Jul.
Article
in English
| MEDLINE
| ID: mdl-169463
Subject(s)
Carcinoma, Hepatocellular/metabolism , Methylnitrosourea/metabolism , Nitrosourea Compounds/metabolism , Animals , DNA, Neoplasm/biosynthesis , Leukemia L1210/metabolism , Liver/metabolism , Liver Neoplasms , Mice , Mice, Inbred Strains , Molecular Weight , Neoplasm Proteins/biosynthesis , Neoplasms, Experimental/metabolism , RNA, Neoplasm/biosynthesis , Time Factors
3.
J Mol Biol
; 86(3): 577-86, 1974 Jul 05.
Article
in English
| MEDLINE
| ID: mdl-4853466
Subject(s)
Liver/cytology , Ribosomes , Animals , Biometry , Microscopy, Electron , Models, Structural , Rats
4.
Cancer Res
; 34(7): 1536-41, 1974 Jul.
Article
in English
| MEDLINE
| ID: mdl-4365228
Subject(s)
Carcinoma, Hepatocellular/metabolism , DNA, Neoplasm/metabolism , Lipid Metabolism , Liver Neoplasms/metabolism , Liver/metabolism , Neoplasm Proteins/metabolism , Nitrosourea Compounds/metabolism , Nitrosourea Compounds/pharmacology , RNA, Neoplasm/metabolism , Alkylation , Animals , Carbon Radioisotopes , Cell Division , Cell Nucleus/metabolism , Cell-Free System , Cytoplasm/metabolism , Cytosol/metabolism , DNA/metabolism , DNA Repair , DNA, Mitochondrial/metabolism , Kinetics , Mice , Mice, Inbred C3H , Mitochondria/metabolism , Neoplasms, Experimental/metabolism , Proteins/metabolism , RNA/metabolism , RNA, Ribosomal/metabolism , Ribosomes/metabolism , Spleen/metabolism
5.
Cancer Res
; 34(7): 1542-7, 1974 Jul.
Article
in English
| MEDLINE
| ID: mdl-4365229
Subject(s)
Carcinoma, Hepatocellular/metabolism , Liver Neoplasms/metabolism , Liver/metabolism , Neoplasm Proteins/biosynthesis , Nitrosourea Compounds/pharmacology , Protein Biosynthesis , Animals , Carbon Radioisotopes , Cell-Free System , In Vitro Techniques , Kinetics , Male , Mice , Mice, Inbred C3H , Mitochondria, Liver/metabolism , Neoplasms, Experimental/metabolism , Ribosomes/metabolism , Time Factors
6.
Mol Biol
; 7(4): 432-8, 1974 Jan.
Article
in English
| MEDLINE
| ID: mdl-4545135
Subject(s)
Polyribosomes/immunology , Adsorption , Animals , Antigen-Antibody Complex , Antigen-Antibody Reactions , Antigens, Heterophile , Binding Sites , Binding Sites, Antibody , Carbon Radioisotopes , Cell Line , Isotope Labeling , Leucine , Mice , Mice, Inbred BALB C , Orotic Acid , Perissodactyla/immunology , Phenylalanine , Plasmacytoma/immunology , Plasmacytoma/metabolism , Polyribosomes/metabolism , Protein Binding , RNA, Neoplasm/biosynthesis , Rabbits/immunology , Spectrophotometry, Ultraviolet , Time Factors
7.
Mol Biol
; 7(4): 496-507, 1974 Jan.
Article
in English
| MEDLINE
| ID: mdl-4132953
