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4.
Semin Diagn Pathol ; 25(4): 262-73, 2008 Nov.
Article in English | MEDLINE | ID: mdl-19013892

ABSTRACT

The article reviews the main molecular pathology alterations of endometrial and ovarian carcinomas and melanoma. Several promising drugs targeting the genes most frequently altered in these tumors are under consideration. The most promising signaling pathways to be targeted for therapies in these tumors are the tyrosine kinase receptor (EGFR, HER2, c-KIT), the RAS/B-RAF/MAPK, the PI3K-mTOR, and apoptosis signaling pathways.


Subject(s)
Antineoplastic Agents/pharmacology , Drug Delivery Systems/trends , Genital Neoplasms, Female/drug therapy , Melanoma/drug therapy , Animals , Clinical Trials as Topic , Drug Delivery Systems/methods , Female , Genital Neoplasms, Female/genetics , Humans , Melanoma/genetics
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