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1.
Am J Trop Med Hyg ; 109(5): 1129-1136, 2023 11 01.
Article in English | MEDLINE | ID: mdl-37783460

ABSTRACT

In rural Uganda, many people who are ill consult traditional healers prior to visiting the formal healthcare system. Traditional healers provide supportive care for common illnesses, but their care may delay diagnosis and management of illnesses that can increase morbidity and mortality, hinder early detection of epidemic-prone diseases, and increase occupational risk to traditional healers. We conducted open-ended, semi-structured interviews with a convenience sample of 11 traditional healers in the plague-endemic West Nile region of northwestern Uganda to assess their knowledge, practices, and attitudes regarding plague and the local healthcare system. Most were generally knowledgeable about plague transmission and its clinical presentation and expressed willingness to refer patients to the formal healthcare system. We initiated a public health outreach program to further improve engagement between traditional healers and local health centers to foster trust in the formal healthcare system and improve early identification and referral of patients with plaguelike symptoms, which can reflect numerous other infectious and noninfectious conditions. During 2010-2019, 65 traditional healers were involved in the outreach program; 52 traditional healers referred 788 patients to area health centers. The diagnosis was available for 775 patients; malaria (37%) and respiratory tract infections (23%) were the most common diagnoses. One patient had confirmed bubonic plague. Outreach to improve communication and trust between traditional healers and local healthcare settings may result in improved early case detection and intervention not only for plague but also for other serious conditions.


Subject(s)
Plague , Traditional Medicine Practitioners , Humans , Uganda/epidemiology , Plague/diagnosis , Plague/epidemiology , Plague/therapy , Delivery of Health Care , Referral and Consultation , Medicine, African Traditional
2.
Int J Infect Dis ; 64: 80-84, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28935246

ABSTRACT

BACKGROUND: Plague is a virulent zoonosis reported most commonly from Sub-Saharan Africa. Early treatment with antibiotics is important to prevent mortality. Understanding knowledge gaps and common behaviors informs the development of educational efforts to reduce plague mortality. METHODS: A multi-stage cluster-sampled survey of 420 households was conducted in the plague-endemic West Nile region of Uganda to assess knowledge of symptoms and causes of plague and health care-seeking practices. RESULTS: Most (84%) respondents were able to correctly describe plague symptoms; approximately 75% linked plague with fleas and dead rats. Most respondents indicated that they would seek health care at a clinic for possible plague; however plague-like symptoms were reportedly common, and in practice, persons sought care for those symptoms at a health clinic infrequently. CONCLUSIONS: Persons in the plague-endemic region of Uganda have a high level of understanding of plague, yet topics for targeted educational messages are apparent.


Subject(s)
Health Knowledge, Attitudes, Practice , Plague , Adolescent , Adult , Aged , Aged, 80 and over , Animals , Anti-Bacterial Agents/therapeutic use , Child , Endemic Diseases , Female , Health Behavior , Humans , Male , Middle Aged , Plague/drug therapy , Plague/epidemiology , Rats , Siphonaptera , Uganda/epidemiology , Young Adult
3.
Emerg Infect Dis ; 23(9): 1517-1521, 2017 09.
Article in English | MEDLINE | ID: mdl-28820134

ABSTRACT

Plague is a highly virulent fleaborne zoonosis that occurs throughout many parts of the world; most suspected human cases are reported from resource-poor settings in sub-Saharan Africa. During 2008-2016, a combination of active surveillance and laboratory testing in the plague-endemic West Nile region of Uganda yielded 255 suspected human plague cases; approximately one third were laboratory confirmed by bacterial culture or serology. Although the mortality rate was 7% among suspected cases, it was 26% among persons with laboratory-confirmed plague. Reports of an unusual number of dead rats in a patient's village around the time of illness onset was significantly associated with laboratory confirmation of plague. This descriptive summary of human plague in Uganda highlights the episodic nature of the disease, as well as the potential that, even in endemic areas, illnesses of other etiologies might be being mistaken for plague.


Subject(s)
Animals, Wild/virology , Disease Outbreaks , Plague/diagnosis , Plague/epidemiology , Yersinia pestis/isolation & purification , Adolescent , Adult , Aged , Animals , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Middle Aged , Plague/classification , Plague/mortality , Rats , Uganda/epidemiology , Yersinia pestis/classification
4.
Emerg Infect Dis ; 23(3)2017 03.
Article in English | MEDLINE | ID: mdl-28125398

ABSTRACT

The US Food and Drug Administration recently approved ciprofloxacin for treatment of plague (Yersina pestis infection) based on animal studies. Published evidence of efficacy in humans is sparse. We report 5 cases of culture-confirmed human plague treated successfully with oral ciprofloxacin, including 1 case of pneumonic plague.


Subject(s)
Anti-Bacterial Agents/therapeutic use , Ciprofloxacin/therapeutic use , Plague/drug therapy , Adolescent , Adult , Child , Female , Humans , Male , Middle Aged , Plague/epidemiology , Uganda/epidemiology
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