[Nuclease activity in multiple trauma]. / Aktivnost' nukleaz pri mnozhestvennoi travme.

Activities of acid and alkaline DNAses and RNAses as well as content of insulin were studied in blood of patients with severe mechanical trauma. Distinct alterations in activities of acid and alkaline DNAses were observed in the acute period of the disease and the activity was normalized within 14-21 days. The RNAase system exhibited the most pronounced response to the trauma, while activity of acid RNAase exceeded the normal level by 52% within 21 days of the posttraumatic period. Activities of acid and alkaline RNAases were increased simultaneously with elevation of the insulin content in blood within 14-21 days of the disease. Thus, alterations in the nucleases activity proved to be a sensitive response of a body to mechanical trauma.

[Free and protein-bound corticosterone levels of the plasma of white rats under hypoxia and after administration of adrenocorticotropic hormone]. / Soderzhanie svobodnogo i sviazannogo s belkom kortikosterona v plazme belykh krys pri gipoksii i posle vvedeniia adrenokortikotropnogo gormona.

It has been demonstrated that the plasma ratio of free and protein-bound corticosterone depends on the hypoxic degree. After two-hour hypoxia at an altitude of 10,000 m the trained and untrained animals exhibit a similar content of the free hormone (21%), with the content of total corticosterone being significantly lower in the trained rats. A study of variations in the content of free corticosterone in rats exposed to hypoxia for 20, 45 and 120 min and ACTH administration during the same time intervals has shown that the binding capacity of transcortine changes 45 min after the beginning of hypoxia.

[Free plasma and cerebral amino acids in children with Down's syndrome]. / Svobodnye aminokisloty plazmy krovi i golovnogo mozga u detei s sindromom Dauna.

In 25 children with Down's syndrome, the content of free amino acids in the blood plasma, was examined chromatographically. The content of free phenylalanine, thyrosine, lysine, histidine, tryptophan, leucine and isoleucine was found to be lowered. In the brain cortex of newborn infants with Down's syndrome and increased content of cystine, alanine, phenylalanine, threonine, leucine, isoleucine, as well as double excess of gamma-aminobutyric acid were revealed.