1.
Eur J Immunol
; 49(5): 812-815, 2019 05.
Article
in English
| MEDLINE
| ID: mdl-30218581
ABSTRACT
We found that deletion of the final 30 amino acids of transcription factor IRF4's (interferon-regulatory factor) C-terminus creates hyperactive IRF4. When introduced into IRF4-deficient CD4+ or CD8+ T cells, more type 17 differentiation was found compared to WT IRF4. Interestingly, Th9 differentiation and Th2-linked IL-13 production were much less altered.
