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1.
Bone Jt Open ; 5(6): 457-463, 2024 Jun 02.
Article in English | MEDLINE | ID: mdl-38823797

ABSTRACT

Aims: Proximal femur fractures treatment can involve anterograde nailing with a single or double cephalic screw. An undesirable failure for this fixation is screw cut-out. In a single-screw nail, a tip-apex distance (TAD) greater than 25 mm has been associated with an increased risk of cut-out. The aim of the study was to examine the role of TAD as a risk factor in a cephalic double-screw nail. Methods: A retrospective study was conducted on 112 patients treated for intertrochanteric femur fracture with a double proximal screw nail (Endovis BA2; EBA2) from January to September 2021. The analyzed variables were age, sex, BMI, comorbidities, fracture type, side, time of surgery, quality of reduction, pre-existing therapy with bisphosphonate for osteoporosis, screw placement in two different views, and TAD. The last follow-up was at 12 months. Logistic regression was used to study the potential factors of screw cut-out, and receiver operating characteristic curve to identify the threshold value. Results: A total of 98 of the 112 patients met the inclusion criteria. Overall, 65 patients were female (66.3%), the mean age was 83.23 years (SD 7.07), and the mean follow-up was 378 days (SD 36). Cut-out was observed in five patients (5.10%). The variables identified by univariate analysis with p < 0.05 were included in the multivariate logistic regression model were screw placement and TAD. The TAD was significant with an odds ratio (OR) 5.03 (p = 0.012) as the screw placement with an OR 4.35 (p = 0.043) in the anteroposterior view, and OR 10.61 (p = 0.037) in the lateral view. The TAD threshold value identified was 29.50 mm. Conclusion: Our study confirmed the risk factors for cut-out in the double-screw nail are comparable to those in the single screw. We found a TAD value of 29.50 mm to be associated with a risk of cut-out in double-screw nails, when good fracture reduction is granted. This value is higher than the one reported with single-screw nails. Therefore, we suggest the role of TAD should be reconsidered in well-reduced fractures treated with double-screw intramedullary nail.

2.
Med Glas (Zenica) ; 21(1): 208-213, 2024 Feb 01.
Article in English | MEDLINE | ID: mdl-38341752

ABSTRACT

Aim Significant risk factors for femoral nail cutout are well-documented, primarily in the context of single-screw proximal nails. However, it remains uncertain whether those same risk factors are applicable when considering different implant devices. The aim of this retrospective cohort study was to compare cutout risk factors between single- versus double-screw proximal femoral nails. Methods Patients over the age of 75 with intertrochanteric femur fractures (AO Classification 31-A1 or 31-A2) were included in the multicentre study. A study group was treated with a double-screw nail, while a control group received single-screw device. Demographic data, surgical time (min), fracture pattern, distal locking, reduction quality, comorbidities, tip-apex distance (TAD) and 12-month functional scores was collected. Results Two hundred patients were enrolled, 100 for each group. Nine patients experienced a cutout complication, five in the study and four in the control group. The main differences were in distal locking configurations (p<0.05) and in TAD values (p<0.05). The TAD value was higher in the study than in the control group (30.40±0.89 versus 26.79±1.79). No differences at 12-month follow up were reported according to functional scores. Conclusion This study provides insights into the choice of nail systems for intertrochanteric femur fractures, highlighting the importance of distal locking configurations and TAD values. The double screw nail exhibits quite a tolerance by having a higher average TAD value. These findings may guide clinical decisionmaking in the treatment of this challenging fracture type.

3.
Injury ; 54 Suppl 1: S46-S52, 2023 Mar.
Article in English | MEDLINE | ID: mdl-33234266

ABSTRACT

Fracture healing is a complex physiologic process, relying on the crucial interplay between biological and mechanical factors. It is generally assessed using imaging modalities, including conventional radiology, CT, MRI and ultrasound (US), based on the fracture and patient features. Although these techniques are routinely used in orthopaedic clinical practice, unfortunately, they do not provide any information about the biomechanical status of the fracture site. Therefore, in recent years, several non-invasive techniques have been proposed to assess bone healing using ultrasonic wave propagation, changes in electrical properties of bones and callus stiffness measurement. Moreover, different research groups are currently developing smart orthopaedic implants (plates, intramedullary nails and external fixators), able to provide information about the fracture healing process. These devices could significantly improve orthopaedic and trauma clinical practice in the future and, at the same time, reduce patients' exposure to X-rays. This study aims to define the role of traditional imaging techniques and emerging technologies in the assessment of the fracture healing process.


Subject(s)
Fracture Fixation, Intramedullary , Fractures, Bone , Orthopedics , Humans , Fracture Healing , Fractures, Bone/diagnostic imaging , Fractures, Bone/surgery , External Fixators
4.
Med Glas (Zenica) ; 20(1)2023 Feb 01.
Article in English | MEDLINE | ID: mdl-36574271

ABSTRACT

Aim To demonstrate a reduction of risk factors ray-depending in proximal femur nailing of intertrochanteric femur fractures, comparing standard technique with computer-assisted navigation system. Methods One hundred patients hospitalised between October 2021 and June 2022 with intertrochanteric femur fractures type 31-A1 and 31-A2 were prospectively enrolled and divided randomly into two groups. A study group was treated with computer-assisted navigation system ATLAS (Masmec Biomed, Modugno, Bari, Italy) (20 patients), while a control group received the standard nailing technique. The same intertrochanteric nail was implanted by a single senior surgeon, Endovis BA 2 (EBA2, Citieffe, Calderara di Reno, Bologna, Italy). The following data were recorded: the setup time of operating room (STOR; minutes); surgical time (ST; minutes); radiation exposure time (ETIR; seconds) and dose area product (DAP; cGy·cm2). Results Patients underwent femur nailing with computer-assisted navigation system reported more set-up time of operating room (24.87±4.58; p<0.01), less surgical time (26.15±5.80; p<0.01), less time of radiant exposure (4.84±2.07; p<0.01) and lower dose area product (16.26±2.91; p<0.01). Conclusion The preliminary study demonstrated that computerassisted navigation allowed a better surgical technique standardization, significantly reduced exposure to ionizing radiation, including a reduction in surgical time. The ATLAS system could also play a key role in residents improving learning curve.

5.
Medicina (Kaunas) ; 58(11)2022 Oct 27.
Article in English | MEDLINE | ID: mdl-36363493

ABSTRACT

Background and Objectives: To assess the effect of continuous cold flow (CCF) therapy on pain reduction, opioid consumption, fast recovery, less perioperative bleeding and patient satisfaction in patients undergoing a total knee arthroplasty. Materials and Methods: Patients affected by knee osteoarthritis between September 2020 and February 2022 were enrolled in this case-control study. Patients were randomly divided into two groups (n = 50, each): the study group received postoperative CCF therapy while the control group was treated by cold pack (gel ice). The CCF device is a computer-assisted therapy with continuous cold fluid, allowing a selective distribution, constant and uniform, of cold or hot on the areas to be treated. In both groups, pre- and postoperative evaluations at 6, 24, 72 h and at the fifth day were conducted using Visual Analogic Scale (VAS), opioid consumption, passive range of motion, preoperative hematocrit, total blood loss by Gross formula, transfusion requirement and patient satisfaction questionnaire. Results: One hundred patients, 52 women (52%), were included in the study. Reduction of pain, opioid consumption and increase in passive range of movement were statistically significantly demonstrated in the study group on the first and third days. Patients were satisfied with adequate postoperative pain management due to CCF therapy (p = 0.01) and they would recommend this treatment to others (p = 0.01). Conclusions: A continuous cold flow device in the acute postoperative setting after total knee arthroplasty is associated with pain reduction and improving early movement. Patients were almost satisfied with the procedure. The management of perioperative pain control could improve participation in the early rehabilitation program as demonstrated by the increase in ROM, psychological satisfaction and reduction in opioid use.


Subject(s)
Arthroplasty, Replacement, Knee , Humans , Female , Arthroplasty, Replacement, Knee/adverse effects , Arthroplasty, Replacement, Knee/rehabilitation , Analgesics, Opioid/therapeutic use , Pain, Postoperative/drug therapy , Range of Motion, Articular , Case-Control Studies , Treatment Outcome
6.
Molecules ; 27(11)2022 May 26.
Article in English | MEDLINE | ID: mdl-35684363

ABSTRACT

Impaired autophagy, responsible for increased inflammation, constitutes a risk factor for the more severe COVID-19 outcomes. Spermidine (SPD) is a known autophagy modulator and supplementation for COVID-19 risk groups (including the elderly) is recommended. However, information on the modulatory effects of eugenol (EUG) is scarce. Therefore, the effects of SPD and EUG, both singularly and in combination, on autophagy were investigated using different cell lines (HBEpiC, SHSY5Y, HUVEC, Caco-2, L929 and U937). SPD (0.3 mM), EUG (0.2 mM) and 0.3 mM SPD + 0.2 mM EUG, significantly increased autophagy using the hallmark measure of LC3-II protein accumulation in the cell lines without cytotoxic effects. Using Caco-2 cells as a model, several crucial autophagy proteins were upregulated at all stages of autophagic flux in response to the treatments. This effect was verified by the activation/differentiation and migration of U937 monocytes in a three-dimensional reconstituted intestinal model (Caco-2, L929 and U937 cells). Comparable benefits of SPD, EUG and SPD + EUG in inducing autophagy were shown by the protection of Caco-2 and L929 cells against lipopolysaccharide-induced inflammation. SPD + EUG is an innovative dual therapy capable of stimulating autophagy and reducing inflammation in vitro and could show promise for COVID-19 risk groups.


Subject(s)
COVID-19 Drug Treatment , Syzygium , Aged , Autophagy , Caco-2 Cells , Eugenol/pharmacology , Humans , Inflammation , Monocytes , Plant Oils , Spermidine/pharmacology , Triticum
7.
Med Glas (Zenica) ; 18(1): 260-266, 2021 02 01.
Article in English | MEDLINE | ID: mdl-33655742

ABSTRACT

Aim To investigate the role of cordonal blood platelet-rich plasma (PRP) intra-articular injections for treating the patients with knee osteoarthritis in terms of procedure safety and clinical outcomes. Methods Twenty-five patients affected by knee osteoarthritis were enrolled and received one single intra-articular knee injection of umbilical cord PRP in a volume of 10 mL. A follow-up was investigated at time 0, 4, 8, 12 weeks and 6 months, evaluating clinical parameters and functional performances. Results No serious adverse events were identified. The paired ttest analysis showed a significant difference between baseline and each follow-up times for all clinical scales (p<0.05), with a significant improvement of clinical outcomes. Conclusion Allogeneic PRP can generate reliable therapeutic effect. The high content of tissue regenerative factors in cord blood platelets makes cordonal blood one of the ideal sources of PRP.


Subject(s)
Osteoarthritis, Knee , Fetal Blood , Humans , Hyaluronic Acid , Injections, Intra-Articular , Osteoarthritis, Knee/therapy , Treatment Outcome
8.
Int Orthop ; 43(1): 193-200, 2019 01.
Article in English | MEDLINE | ID: mdl-30488127

ABSTRACT

INTRODUCTION: Femoral shaft fractures with third fragments have a high non-union rate, which may reach 14%. This study aims to assess the impact of the radiological features of the third fragment, evaluated on post-operative X-rays, on the outcome of femoral shaft fractures type 32-B managed with intramedullary nailing, in order to obtain an algorithm which could predict the fracture healing time. MATERIALS AND METHODS: We have retrospectively evaluated a series of 52 patients. On post-operative X-rays, four radiological parameters were evaluated: the third fragment angle, the fracture gap, the third fragment size, and the mean third fragment displacement. All the patients underwent a radiologic follow-up at one, two, three, six, nine and 12 months post-operatively, to assess the bone healing. The patients were then divided into three groups, according to the fracture healing time: within six months (group A), between six and 12 months (group B), or fracture non-union after 12 months (group C). RESULTS: In 28 patients, out of 52 (53.85%), the fracture healing was observed at 6-month follow-up; in 18 patients, out of 52 (34.62%), the fracture healed within 12 months after trauma; and in six patients, out of 52 (11.54%), no fracture healing was observed at 12-month follow-up. The mean third fragment size was significantly different in each group (p < 0.05), while the mean third fragment displacement was significantly higher in group C, compared with group A (p = 0.0006) and group B (p = 0.0027). In group B, a positive correlation was found between the fracture healing time and the mean third fragment size (R = 0.594, p = 0.036); in group C, the fracture union time was positively related to the third fragment size (R = 0.689, p = 0.013) and the mean third fragment displacement (R = 0.7107, p = 0.006). Regression analysis showed that the third fragment size and the mean third fragment displacement are the most important features which affect the fracture healing time. CONCLUSIONS: The third fragment size (cutoff 40 mm) is the leading parameter to influence the fracture healing within or in more than six months. The mean third fragment displacement (cutoff 12 mm); on the other hand, impacts on the fracture delayed rather than absent healing.


Subject(s)
Femoral Fractures/diagnostic imaging , Femur/diagnostic imaging , Fracture Fixation, Intramedullary , Fracture Healing , Fractures, Ununited/diagnostic imaging , Adult , Aged , Algorithms , Bone Nails , Diaphyses/diagnostic imaging , Diaphyses/physiopathology , Diaphyses/surgery , Female , Femoral Fractures/physiopathology , Femoral Fractures/surgery , Femur/physiopathology , Femur/surgery , Fractures, Ununited/physiopathology , Humans , Male , Middle Aged , Retrospective Studies , Risk Assessment , Treatment Outcome , Young Adult
9.
Injury ; 48 Suppl 3: S60-S65, 2017 Oct.
Article in English | MEDLINE | ID: mdl-29025612

ABSTRACT

We investigated functional and radiological outcome in 57 cases of midshaft clavicle nonunion treated with open reduction and internal fixation with plate and screws over a 13 year-period. Intercalary bone graft was used in 42 patients; opposite autologous strut graft was used in 31 cases to provide mechanical support to the host bone. Patients were analysed using chart and radiological review and assessed with DASH questionnaire obtained at the latest follow-up. 37 patients were male while 20 were females, with a mean age of 35 years (63-17). All cases were of nonunion, 35 atrophic and 22 hypertrophic. The dominant side was injured in 32 cases and the non dominant in 25 cases. Primarily, 43 cases were treated conservatively with a figure of eight bandage. Time between fracture and our operative treatment was on average 44 months (13-72 months). Only those patients who were symptomatic were included in this study. We used straight reconstruction LCP and low profile precontoured plates. By reviewing patients charts all the cases but one of nonunion progressed to osseous healing at a mean time of 14 weeks (range 12-16). The patient with non-union refused further surgery. 49 patients were available for a final follow up. DASH score was 16.7 at an average of 42 months. Open surgery and internal fixation, using plate and screws in a compression construct is the treatment of choice for symptomatic clavicular non-unions. Intercalary autologous or allograft bone graft should be used especially in patient with significant bone loss; autologous cortical strut graft provides optimum mechanical stability, thus assuring optimal screw purchase and allowing immediate limb movement.


Subject(s)
Bone Transplantation , Clavicle/surgery , Fracture Healing/physiology , Fractures, Bone/surgery , Fractures, Ununited/surgery , Open Fracture Reduction , Radiography , Adolescent , Adult , Bone Transplantation/methods , Clavicle/diagnostic imaging , Clavicle/injuries , Clavicle/physiopathology , Female , Follow-Up Studies , Fractures, Bone/diagnostic imaging , Fractures, Bone/physiopathology , Fractures, Ununited/diagnostic imaging , Fractures, Ununited/physiopathology , Humans , Male , Middle Aged , Recovery of Function/physiology , Retrospective Studies , Surveys and Questionnaires , Treatment Outcome , Young Adult
10.
Injury ; 47 Suppl 4: S131-S137, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27484831

ABSTRACT

OBJECTIVES: To determine the efficacy of hybrid external fixation in the treatment of tibial pilon fractures. DESIGN: Retrospective, multicentre study. PATIENTS/PARTICIPANTS: Adult patients with tibial pilon fractures treated with hybrid external fixation. INTERVENTION: Fracture reduction with ligamentotaxis and fixation with XCaliber hybrid external fixator. MAIN OUTCOME MEASUREMENTS: Fracture union, complications, functional outcome (Mazur Ankle Score). RESULTS: Union was obtained in 159 fractures at an average of 125days; there were three delayed unions and three non-unions. The most frequent complication was superficial pin-track infections (48), all of which responded to local wound care and antibiotics. There were no deep infections and no DVT. Only one fracture had loss of reduction that required frame revision. The overall functional scores were 91 (excellent) for AO/OTA type A fractures, 89 (good) for type B fractures, and 75 (satisfactory) for type C fractures. CONCLUSIONS: Hybrid external fixation is an effective method of stabilising tibial pilon fractures, particularly those with marked comminution. The minimally-invasive technique and stable fixation enable early mobilisation, with good functional results and minimal complications. LEVEL OF EVIDENCE: Level IV Case series.


Subject(s)
Ankle Injuries/surgery , Ankle Joint/surgery , External Fixators , Fluoroscopy , Fracture Fixation , Surgical Wound Infection/prevention & control , Tibial Fractures/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Ankle Injuries/diagnostic imaging , Ankle Injuries/physiopathology , Ankle Joint/diagnostic imaging , Ankle Joint/physiopathology , Female , Follow-Up Studies , Fracture Fixation/instrumentation , Fracture Fixation/methods , Humans , Male , Middle Aged , Retrospective Studies , Supine Position , Tibial Fractures/diagnostic imaging , Tibial Fractures/physiopathology , Treatment Outcome , Young Adult
11.
Injury ; 47 Suppl 4: S84-S90, 2016 Oct.
Article in English | MEDLINE | ID: mdl-27503313

ABSTRACT

PURPOSE: To compare clinical outcomes of ORIF with volar locking plates and the Epibloc system (ES) in the treatment of distal radius fractures (DRFs) in patients aged over 65 years. METHODS: We retrospectively examined a consecutive series of 100 patients with intra-articular or extra-articular DRF who were admitted to our Department of Orthopaedics and Traumatology between January 2007 and January 2013. Fifty patients were treated using the Epibloc System; and the other 50 patients using ORIF with volar locking plates. In all patients, functional evaluation (wrist range of motion [ROM], grip strength and Disability of the Arm, Shoulder and Hand [DASH] Score) and radiographic assessment (radial inclination, volar tilt, ulnar variance and articular congruity) were performed at 2 and 6 weeks, and 3, 6 and 12 months postoperatively; then every 12 months thereafter. RESULTS: ORIF with volar locking plates was associated with better outcome than ES in the intra-articular and extra-articular DRF groups, generating higher average ROM, DASH and visual analogue scale (VAS) scores. Grip strength mean values, however, were quantified over the minimum level for a functional wrist (>60%) in both groups. There were no differences between the two techniques in X-ray parameters, and no further correlation was found with functional outcome and ROM. CONCLUSIONS: In a low-functioning patient with multiple medical comorbidities, minimally-invasive surgery with the ES is a safe option, enables early mobilisation of the wrist and is likely to produce acceptable clinical outcomes.


Subject(s)
Fracture Fixation , Intra-Articular Fractures/surgery , Radius Fractures/surgery , Wrist Joint/physiopathology , Aged , Aged, 80 and over , Bone Plates , Comorbidity , Disability Evaluation , External Fixators , Female , Follow-Up Studies , Fracture Fixation/instrumentation , Hand Strength , Humans , Intra-Articular Fractures/diagnostic imaging , Intra-Articular Fractures/physiopathology , Italy , Male , Radius Fractures/diagnostic imaging , Radius Fractures/physiopathology , Range of Motion, Articular , Recovery of Function , Retrospective Studies , Treatment Outcome , Wrist Joint/diagnostic imaging , Wrist Joint/surgery
12.
Aging Clin Exp Res ; 27 Suppl 1: S77-83, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26215317

ABSTRACT

PURPOSE: To evaluate the clinical outcomes of radial head excision for multifragmentary radial head fracture in patients over 65 years old. METHODS: We retrospectively examined 30 patients over 65 years of age treated with radial head excision for comminuted radial head fractures. Patients were evaluated through clinical examinations, administrative questionnaires (DASH--Disabilities of the Arm, Shoulder and Hand; MEPS--Mayo Elbow Performance Score, VAS--Visual Analog Scale) and plain films. RESULTS: The mean follow-up was 40 months (range 24-72 months); 27 out of 30 patients claimed to be satisfied. The mean DASH score was 13 (range 3-45.8) and mean MEPS was 79 (range 65-97). The radiographic evaluation showed 21 cases of elbow arthritis; only two of them complained about pain. Heterotopic ossification was evident in six cases with functional impairment in only one patient. Six patients with increased ulnar variance had clinical distal radio-ulnar joint instability. DISCUSSION: Radial head excision has been considered a safe surgical procedure with satisfactory clinical outcomes. Development in biomechanical studies and prosthetic replacement of the radial head question the validity of radial head excision. In current literature, there are neither long-term follow-up studies on radial head prosthesis outcomes nor studies which consider elderly patient samples. CONCLUSION: Radial head resection remains a good option when a radial head fracture occurs in elderly patients, taking into account the influence of poor bone quality and comorbidities on the outcome. Radial head excision is not indicated in the presence of associated lesions, because of the risk of residual elbow instability; complications associated with advanced age must be considered and a strict follow-up granted.


Subject(s)
Elbow Joint/surgery , Fractures, Comminuted , Orthopedic Procedures , Postoperative Complications , Radius Fractures , Aged , Aged, 80 and over , Elbow Joint/diagnostic imaging , Elbow Joint/physiopathology , Female , Fractures, Comminuted/diagnosis , Fractures, Comminuted/surgery , Humans , Male , Orthopedic Procedures/adverse effects , Orthopedic Procedures/methods , Outcome Assessment, Health Care , Postoperative Complications/diagnosis , Postoperative Complications/etiology , Prognosis , Radiography , Radius/pathology , Radius/surgery , Radius Fractures/diagnosis , Radius Fractures/surgery , Range of Motion, Articular , Retrospective Studies , Risk Factors , Surveys and Questionnaires
13.
Joints ; 3(4): 208-14, 2015.
Article in English | MEDLINE | ID: mdl-26904527

ABSTRACT

Periprosthetic joint infection (PJI) remains one of the most challenging complications after joint arthroplasty. Despite improvements in surgical techniques and in the use of antibiotic prophylaxis, it remains a major cause of implant failure and need for revision. PJI is associated with both human host-related and bacterial agent-related factors that can interact in all the phases of the procedure (preoperative, intraoperative and postoperative). Prevention is the first strategy to implement in order to minimize this catastrophic complication. The present review focuses on the preoperative period, and on what to do once risk factors are fully understood and have been identified.

14.
Injury ; 46 Suppl 7: S11-6, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26738452

ABSTRACT

A 25-year-old man was admitted to our Department with an open humeral shaft fracture (Gustilo III C); two large wounds were noticed with ulnar artery and median nerve completely dissected. Initial primary treatment included irrigation, debridement and fracture stabilization with a monolateral external fixator followed by vascular and nerve repair and wound closure. At 6 months follow up the patient was able to use his arm without any painful stimuli and a CT scan showed the presence of postero-medial callus formation. Consequently, the external fixator was removed and the patient was discharged to physiotherapy. After 7 months, the patient presented with severe pain and functional impairment with no history of trauma. X rays showed recent re-fracture on a background of oligotrophic nonunion. Revision surgery included debridement of the non-union bone edges, reaming of the medullary canal and insertion of a humeral nail. Six months later osseous healing was noted with complete restoration of shoulder and elbow movement and partial recovery of the median nerve.


Subject(s)
External Fixators , Fracture Fixation, Intramedullary , Fractures, Ununited/surgery , Humeral Fractures/surgery , Median Nerve/injuries , Median Neuropathy/surgery , Postoperative Complications/surgery , Ulnar Artery/injuries , Accidents, Traffic , Adult , Anti-Bacterial Agents/administration & dosage , Bone Nails , Bone Plates , Fracture Healing , Fractures, Ununited/complications , Fractures, Ununited/diagnostic imaging , Humans , Humeral Fractures/complications , Humeral Fractures/diagnostic imaging , Male , Median Neuropathy/etiology , Median Neuropathy/physiopathology , Postoperative Complications/diagnostic imaging , Postoperative Complications/physiopathology , Reoperation , Treatment Outcome
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