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New steroidal derivatives synthesized using 3beta-hydroxyandrosten-17-one as starting material.
Abd El-Latif, Nehad A; Abdulla, Mohamed M; Amr, Abd El-Galil E.
Acta Pharm ; 58(1): 43-59, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18337207

ABSTRACT

In this study, we synthesized some new substituted steroidal derivatives using 3beta-hydroxyandrosten-17-one (dehydroepiandrosterone) as starting material. The synthesized steroidal derivatives 1-11 were evaluated for their androgenic-anabolic activities compared to testosterone as positive control. Details of the synthesis, spectroscopic data and toxicity (LD50) of synthesized compounds are reported.


Subject(s)
Anabolic Agents/chemical synthesis , Androgens/chemical synthesis , Androstanols/chemical synthesis , Androstenes/chemical synthesis , Dehydroepiandrosterone/analogs & derivatives , Drug Design , Anabolic Agents/chemistry , Anabolic Agents/pharmacology , Androgens/chemistry , Androgens/pharmacology , Androstanols/chemistry , Androstanols/pharmacology , Androstanols/toxicity , Androstenes/chemistry , Androstenes/pharmacology , Androstenes/toxicity , Animals , Dehydroepiandrosterone/chemistry , Drug Evaluation, Preclinical , Genitalia, Male/drug effects , Lethal Dose 50 , Male , Molecular Structure , Muscles/drug effects , Organ Size , Rats , Rats, Sprague-Dawley , Structure-Activity Relationship
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