Bishydrazone ligand and its Zn-complex: synthesis, characterization and estimation of scalability inhibition mitigation effectiveness for API 5L X70 carbon steel in 3.5% NaCl solutions.

Bishydrazone ligand, 2,2'-thiobis(N'-((E)-thiophen-2-ylmethylene) acetohydrazide), H2TTAH and its Zn- complex were prepared and characterized through elemental analysis and various spectroscopic performances as well as (IR, 1H and 13C NMR, mass and (UV-Vis) measurements. The synthesized complex exhibited the molecular formula [Zn2(H2TTAH)(OH)4(C5H5N)3C2H5OH] (Zn-H2TTAH). To assess their potential as anti-corrosion materials, the synthesized particles were assessed for their effectiveness for API 5L X70 C-steel corrosion in a 3.5% NaCl solution using electrochemical methods such as potentiodynamic polarization (PP) and electrochemical impedance spectroscopy (EIS). Additionally, X-ray photoelectron spectroscopy (XPS) was employed to examine the steel surface treated with the tested inhibitors, confirming the establishment of an adsorbed protecting layer. The results obtained from the PP plots indicated that both H2TTAH and Zn-H2TTAH act as mixed-type inhibitors. At a maximum concentration of 1 × 10-4 M, H2TTAH and Zn-H2TTAH exhibited inhibition efficiencies of 93.4% and 96.1%, respectively. The adsorption of these inhibitors on the steel surface followed the Langmuir adsorption isotherm, and it was determined to be chemisorption. DFT calculations were achieved to regulate the electron donation ability of H2TTAH and Zn-H2TTAH molecules. Additionally, Monte Carlo (MC) simulations were conducted to validate the adsorption configurations on the steel surface and gain insight into the corrosion inhibition mechanism facilitated by these molecules.

Corrosion Mitigation Performance of N80 Steel in 5% Sulfamic Acid Medium by Applying Novel Tetrahydro-1,2,4-triazines Including Triazene Moieties: Electrochemical and Theoretical Approaches.

We observed our newly developed tetrahydro-1,2,4-triazines, including triazene moieties (THTA), namely, 6-((1E)-1-((2E)-(4-(((Z)-1-(2,4-diphenyl-2,3,4,5-tetrahydro-1,2,4-triazin-5-yl) ethylidene) triaz-1-en-1-yl)piperazin-1-yl) triaz-2-en-1-ylidene) ethyl)-2,4-diphenyl-2,3,4,5-tetrahydro-1,2,4-triazine (THTA-I), and 1-((E)-((E)-1-(2,4-diphenyl-2,3,4,5-tetrahydro-1,2,4-triazin-6-yl) ethylidene) triaz-1-en-1-yl) naphthalen-2-ol (THTA-II), as effective inhibitors for the corrosion protection of N80 carbon steel metal in 5% sulfamic acid as the corrosive medium via electrochemical approaches such as potentiodynamic polarization and electrochemical impedance spectroscopy. Furthermore, the tested steel exterior was monitored using X-ray photoelectron spectroscopy after the treatment with the investigated components to verify the establishment of the adsorbed shielding film. The investigated compounds acted as mixed-type inhibitors, as shown by Tafel diagrams. The compounds considered obey the Langmuir adsorption isotherm, and their adsorption on the steel surface was chemisorption. When the tested inhibitors were added, the double-layer capacitances, which can be determined by the adsorption of the tested inhibitors on N80 steel specimens, decreased compared with that of the blank solution. At 10-4 M, the inhibitory efficacy of THTA-I and THTA-II achieved maximum values of 88.5 and 86.5%, respectively. Density-functional theory computations and Monte-Carlo simulation were applied to determine the adsorption attributes and inhibition mechanism through the studied components. Furthermore, the investigated inhibitors were considered to adsorb on the Fe (1 1 0) surface. The adsorption energy was then measured on steel specimens.

Skin Microbiome Differences in Atopic Dermatitis and Healthy Controls in Egyptian Children and Adults, and Association with Serum Immunoglobulin E.

Atopic dermatitis (AD) is a complex, multifactorial, chronic pruritic inflammatory skin disease. We report the first microbiome study and new insights on the relationship between skin microbiota variation and AD susceptibility in a population sample from Egypt. We characterized the skin microbiome in 75 patients with AD and 20 healthy controls using Illumina MiSeq sequencing of 16S rRNA gene. Overall, bacterial diversity of skin microbiome in patients with AD was less than those of the healthy subjects. Genus level analysis revealed significant abundance variations by age, disease severity, locality, or immune response. Among these genera, Streptococcus, Cutibacterium, and Corynebacterium appeared to be specific signatures for AD in children, adolescents, and adults, respectively, while Staphylococcus was noted as a potential biomarker candidate for AD. Additionally, functional potential of metagenomes shifted the overall metabolic pathways to participate in the exacerbation of disease. Total immunoglobulin E (IgE) levels were positively correlated with relative enrichment of certain Staphylococcus aureus subspecies. Finally, AD-related differences in skin bacterial diversity appeared to be in part linked to the serum IgE level. These new observations attest to the promise of microbiome science and metagenomic analysis in AD specifically, and clinical dermatology broadly.

Quadripolar Left Ventricular Lead in a Patient with CRT-D Does Not Overcome Phrenic Nerve Stimulation.

Effective cardiac resynchronization therapy (CRT) requires an accurate atrio-biventricular pacing system. The innovative Quartet lead is a quadripolar, over-the-wire left ventricular lead with four electrodes and has recently been designed to provide more options and greater control in pacing vector selection. A lead with multiple pacing electrodes is a potential alternative to physical adjustment of the lead and may help to overcome high thresholds and phrenic nerve stimulation (PNS).