Chronic diazinon exposure: pathologies of spleen, thymus, blood cells, and lymph nodes are modulated by dietary protein or lipid in the mouse.

Little is known about the immunotoxicity of the organophosphate pesticide, diazinon. This study aims at detailing the pathologies in the thymus, spleen, blood cells, and lymph nodes (brachial, mesenteric, and hind quarter gluteal nodes) during chronic oral exposure (300 mg diazinonkg-1 food for 45 days), and explore the combined toxicity with excess dietary protein (40%) or lipid (20% corn oil). Animals were allowed to recover on normal food for 2 weeks. All experimental treatments caused organ pathologies, including necrotic degeneration of the trabeculae (spleen and thymus), hyperplasia of the cortex and medulla (thymus and lymph nodes), hyperplasia of white and red pulp (spleen), and sometimes haemorrhage (all tissues). Blood smears often showed crenated/hypochromic red cells and vacuolated white cells with abnormal nuclei. The severity of lesions during exposure was generally in the following order: lipid

The development of the chondrocranium of the lacertid lizard, Acanthodactylus boskiana.

The trabeculae cranii are at first quite separate from each other, after few days their anterior two fifths are connected by a trabecular plate which is obliterated throughout development. The paired origin of the parachordal plate is not observed. The fused posterior orbital cartilages chondrify in the form of a wide short plate, traversed by the oculomotor and trochlear nerves. The basicranial fenestra and fenestra ovalis are formed by the degeneration of pre-existing cartilage. The cochlear portion is completely fused with the parachordal plate from the very beginning. The elements of the pterygoquadrate are fused together. The quadrate and Meckel's cartilage are in close contact from the very beginning. While the lower part of the interorbital septum is derived from the trabecula communis, its upper part is derived from the anterior orbital cartilages. The lateral parts of the fused posterior orbital cartilages give rise to most of the taeniae and pilae of the orbitotemporal region. There is only one commissure between the auditory capsule and parachordal plate. A cartilaginous connection between the distal portion of the columella auris and ceratohyal persists for some time. The parietotectal and paranasal cartilages are fused together from the very beginning. The processus paroticus originates from the columella auris. In the fully formed stage the notochord is completely embedded in the occipital condyle. The union between the condyle and odontoid process persists. The auditory capsules and occipital arches contribute to the formation of the tectum synoticum plus posterius. The prefacial commissure and facial foramen lie in front of the cochlear portion. The columella auris possesses a processus internus (connected with the quadrate), but the processes a dorsalis has completely disappeared. The orbitotemporal region is quite complete. A medial fenestra is formed in the planum supraseptale. A fenestra is observed in each of the interorbital and nasal septa. The lamina transversalis anterior is fused with the parietotectal cartilage. A complete zona annularis is present. The outer wall of the paranasal cartilage is perforated by a large fenestra lateralis. The parietotectal and paranasal cartilages and the posterior process of the lamina transversalis anterior contribute to the formation of the concha nasalis. There is a contact between the planum antorbitale and nasal septum. The pterygoid process has disappeared. The common characters of the lacertid chondrocranuium are deduced.