ABSTRACT
A study on intravenous sedation in dental surgery was conducted comparing diazepam and fentanyl with midazolam and fentanyl. The total number of patients was one hundred and eighty patients. One hundred and twenty patients received diazepam and fentanyl, and later when midazolam was available sixty patients received this drug with fentanyl. The cardiovascular effects, the anterograde amnesia and adverse venous sequelae were investigated. Both drugs gave safe and acceptable sedation. The diazepam group had more venous sequelae. The midazolam group had better amnesia effects with no incidence of venous sequelae.
Subject(s)
Anesthesia, Dental , Anesthesia, Intravenous , Hypnotics and Sedatives , Adolescent , Adult , Aged , Child , Diazepam , Female , Fentanyl , Hemodynamics/drug effects , Humans , Male , Memory/drug effects , Midazolam , Middle Aged , Respiration/drug effectsABSTRACT
Meptazinol, a new analgesic agent, was used to treat chest pain in patients admitted to a coronary care unit with suspected myocardial infarction or unstable angina. A pilot study showed that meptazinol was effective in relieving pain in 15 out of 22 subjects. There were no adverse haemodynamic effects nor respiratory depression. Nausea and/or vomiting occurred with administration of the drug but as these symptoms may occur in patients with myocardial infarction who have not received any analgesia (Ingram et al., 1980), a cause and effect relationship cannot be inferred in this respect. The incidence of other side effects ascribed to meptazinol was low.
Subject(s)
Angina Pectoris/drug therapy , Azepines/therapeutic use , Meptazinol/therapeutic use , Myocardial Infarction/complications , Pain/drug therapy , Cyclizine/therapeutic use , Humans , Injections, Intramuscular , Injections, Intravenous , Meptazinol/adverse effects , Pain/etiologyABSTRACT
In a double-blind study involving 24 patients, treatment with lidoflazine in comparison with placebo was associated with a significant improvement in exercise tolerance; the median increase in work performed was 62 percent. This increase was significant at the 6th week of assessment. Ten patients were followed up for a further 2 years. Lidoflazine therapy was associated with a significant improvement in work done over that period. Lidoflazine was well tolerated and apparent adverse effects were minor.
Subject(s)
Angina Pectoris/drug therapy , Lidoflazine/therapeutic use , Pain/etiology , Piperazines/therapeutic use , Thorax/physiopathology , Adult , Aged , Arrhythmias, Cardiac/diagnosis , Double-Blind Method , Electrocardiography , Exercise Test , Female , Follow-Up Studies , Humans , Lidoflazine/adverse effects , Male , Middle AgedABSTRACT
A 29-year-old man with previous Henoch-Schönlein disease presented with multiple systemic emboli and a myocardial infarction. Subsequent investigation by angiography showed normal coronary arteries. This appears to be the first reported case of Henoch-Schönlein disease and myocardial infarction probably due to coronary vasculitis.
