Feature Importance Analysis and Machine Learning for Alzheimer's Disease Early Detection: Feature Fusion of the Hippocampus, Entorhinal Cortex, and Standardized Uptake Value Ratio.

Introduction: Alzheimer's disease (AD) is a progressive neurological disorder characterized by mild memory loss and ranks as a leading cause of mortality in the USA, accounting for approximately 120,000 deaths per year. It is also the primary form of dementia. Early detection is critical for timely intervention as the neurodegenerative process often starts 15-20 years before cognitive symptoms manifest. This study focuses on determining feature importance in AD classification using fused texture features from 3D magnetic resonance imaging hippocampal and entorhinal cortex and standardized uptake value ratio (SUVR) derived from positron emission tomography (PET) images. Methods: To achieve this objective, we employed four distinct classifiers (Linear Support Vector Classification, Linear Discriminant Analysis, Logistic Regression, and Logistic Regression Classifier with Stochastic Gradient Descent Learning). These classifiers were used to derive both average and top-ranked importance scores for each feature based on their outputs. Our framework is designed to distinguish between two classes, AD-negative (or mild cognitive impairment stable [MCIs]) and AD-positive (or MCI conversion [MCIc]), using a probabilistic neural network classifier and the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. Results: The findings from the feature importance highlight the crucial role of the GLCM texture features extracted from the hippocampus and entorhinal cortex, demonstrating their superior performance compared to the volume and SUVR. GLCM texture AD classification achieved approximately 90% sensitivity in identifying MCIc cases while maintaining low false positives (below 30%) when fused with other features. Moreover, the receiver operating characteristic curves validate the GLCMs' superior performance in distinguishing between MCIs and MCIc. Additionally, fusing different types of features improved classification performance compared to relying solely on any single feature category. Conclusion: Our study emphasizes the pivotal role of GLCM texture features in early Alzheimer's detection.

Towards reliable hepatocytic anatomy segmentation in laparoscopic cholecystectomy using U-Net with Auto-Encoder.

BACKGROUND: Most bile duct (BDI) injuries during laparoscopic cholecystectomy (LC) occur due to visual misperception leading to the misinterpretation of anatomy. Deep learning (DL) models for surgical video analysis could, therefore, support visual tasks such as identifying critical view of safety (CVS). This study aims to develop a prediction model of CVS during LC. This aim is accomplished using a deep neural network integrated with a segmentation model that is capable of highlighting hepatocytic anatomy. METHODS: Still images from LC videos were annotated with four hepatocystic landmarks of anatomy segmentation. A deep autoencoder neural network with U-Net to investigate accurate medical image segmentation was trained and tested using fivefold cross-validation. Accuracy, Loss, Intersection over Union (IoU), Precision, Recall, and Hausdorff Distance were computed to evaluate the model performance versus the annotated ground truth. RESULTS: A total of 1550 images from 200 LC videos were annotated. Mean IoU for segmentation was 74.65%. The proposed approach performed well for automatic hepatocytic landmarks identification with 92% accuracy and 93.9% precision and can segment challenging cases. CONCLUSION: DL, can potentially provide an intraoperative model for surgical video analysis and can be trained to guide surgeons toward reliable hepatocytic anatomy segmentation and produce selective video documentation of this safety step of LC.

3D Autonomous Surgeon's Hand Movement Assessment Using a Cascaded Fuzzy Supervisor in Multi-Thread Video Processing.

The purpose of the Fundamentals of Laparoscopic Surgery (FLS) training is to develop laparoscopic surgery skills by using simulation experiences. Several advanced training methods based on simulation have been created to enable training in a non-patient environment. Laparoscopic box trainers-cheap, portable devices-have been deployed for a while to offer training opportunities, competence evaluations, and performance reviews. However, the trainees must be under the supervision of medical experts who can evaluate their abilities, which is an expensive and time-consuming operation. Thus, a high level of surgical skill, determined by assessment, is necessary to prevent any intraoperative issues and malfunctions during a real laparoscopic procedure and during human intervention. To guarantee that the use of laparoscopic surgical training methods results in surgical skill improvement, it is necessary to measure and assess surgeons' skills during tests. We used our intelligent box-trainer system (IBTS) as a platform for skill training. The main aim of this study was to monitor the surgeon's hands' movement within a predefined field of interest. To evaluate the surgeons' hands' movement in 3D space, an autonomous evaluation system using two cameras and multi-thread video processing is proposed. This method works by detecting laparoscopic instruments and using a cascaded fuzzy logic assessment system. It is composed of two fuzzy logic systems executing in parallel. The first level assesses the left and right-hand movements simultaneously. Its outputs are cascaded by the final fuzzy logic assessment at the second level. This algorithm is completely autonomous and removes the need for any human monitoring or intervention. The experimental work included nine physicians (surgeons and residents) from the surgery and obstetrics/gynecology (OB/GYN) residency programs at WMU Homer Stryker MD School of Medicine (WMed) with different levels of laparoscopic skills and experience. They were recruited to participate in the peg-transfer task. The participants' performances were assessed, and the videos were recorded throughout the exercises. The results were delivered autonomously about 10 s after the experiments were concluded. In the future, we plan to increase the computing power of the IBTS to achieve real-time performance assessment.

Guided Depth Completion with Instance Segmentation Fusion in Autonomous Driving Applications.

Pixel-level depth information is crucial to many applications, such as autonomous driving, robotics navigation, 3D scene reconstruction, and augmented reality. However, depth information, which is usually acquired by sensors such as LiDAR, is sparse. Depth completion is a process that predicts missing pixels' depth information from a set of sparse depth measurements. Most of the ongoing research applies deep neural networks on the entire sparse depth map and camera scene without utilizing any information about the available objects, which results in more complex and resource-demanding networks. In this work, we propose to use image instance segmentation to detect objects of interest with pixel-level locations, along with sparse depth data, to support depth completion. The framework utilizes a two-branch encoder-decoder deep neural network. It fuses information about scene available objects, such as objects' type and pixel-level location, LiDAR, and RGB camera, to predict dense accurate depth maps. Experimental results on the KITTI dataset showed faster training and improved prediction accuracy. The proposed method reaches a convergence state faster and surpasses the baseline model in all evaluation metrics.

Prostate cancer recognition based on mass spectrometry sensing data and data fingerprint recovery.

The high dimensionality and noisy spectra of Mass Spectrometry (MS) data are two of the main challenges to achieving high accuracy recognition. The objective of this work is to produce an accurate prediction of class content by employing compressive sensing (CS). Not only can CS significantly reduce MS data dimensionality, but it will also allow for full reconstruction of original data. We are proposing a weighted mixing of L1- and L2-norms via a regularization term as a classifier within compressive sensing framework. Using performance measures such as OSR, PPV, NPV, Sen and Spec, we show that the L2-algorithm with regularization terms outperforms the L1-algorithm and Q5 under all applicable assumptions. We also aimed to use Block Sparse Bayesian Learning (BSBL) to reconstruct the MS data fingerprint which has also shown better performance results that those of L1-norm. These techniques were successfully applied to MS data to determine patient risk of prostate cancer by tracking Prostate-specific antigen (PSA) protein, and this analysis resulted in better performance when compared to currently used algorithms such as L1 minimization. This proposed work will be particularly useful in MS data reduction for assessing disease risk in patients and in future personalized medicine applications.

Hybrid mammogram classification using rough set and fuzzy classifier.

We propose a computer aided detection (CAD) system for the detection and classification of suspicious regions in mammographic images. This system combines a dimensionality reduction module (using principal component analysis), a feature extraction module (using independent component analysis), and a feature subset selection module (using rough set model). Rough set model is used to reduce the effect of data inconsistency while a fuzzy classifier is integrated into the system to label subimages into normal or abnormal regions. The experimental results show that this system has an accuracy of 84.03% and a recall percentage of 87.28%.

Bayesian classifier with simplified learning phase for detecting microcalcifications in digital mammograms.

Detection of clustered microcalcifications (MCs) in mammograms represents a significant step towards successful detection of breast cancer since their existence is one of the early signs of cancer. In this paper, a new framework that integrates Bayesian classifier and a pattern synthesizing scheme for detecting microcalcification clusters is proposed. This proposed work extracts textural, spectral, and statistical features of each input mammogram and generates models of real MCs to be used as training samples through a simplified learning phase of the Bayesian classifier. Followed by an estimation of the classifier's decision function parameters, a mammogram is segmented into the identified targets (MCs) against background (healthy tissue). The proposed algorithm has been tested using 23 mammograms from the mini-MIAS database. Experimental results achieved MCs detection with average true positive (sensitivity) and false positive (specificity) of 91.3% and 98.6%, respectively. Results also indicate that the modeling of the real MCs plays a significant role in the performance of the classifier and thus should be given further investigation.

Unsupervised Detection of Suspicious Tissue Using Data Modeling and PCA.

Breast cancer is a major cause of death and morbidity among women all over the world, and it is a fact that early detection is a key in improving outcomes. Therefore development of algorithms that aids radiologists in identifying changes in breast tissue early on is essential. In this work an algorithm that investigates the use of principal components analysis (PCA) is developed to identify suspicious regions on mammograms. The algorithm employs linear structure and curvelinear modeling prior to PCA implementations. Evaluation of the algorithm is based on the percentage of correct classification, false positive (FP) and false negative (FN) in all experimental work using real data. Over 90% accuracy in block classification is achieved using mammograms from MIAS database.