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Comp Biochem Physiol B Biochem Mol Biol ; 131(3): 535-42, 2002 Mar.
Article in English | MEDLINE | ID: mdl-11959036

ABSTRACT

We tested the ability of carnosine to improve some liver disorders induced by Schistosoma mansoni parasite in hamsters (Mesocricetus auratus). Results indicate that parasitic infestation induced elevation in serum alkaline phosphatase, gamma-glutamyl transferase, aspartate aminotransferase and procollagen III peptide as a marker of liver fibrosis. Administration of carnosine (10 mg/day) for 15 days either concurrent with infection, 2 and 4 weeks post-infestation was effective in reducing differential worm burden. It was also effective in renormalizing blood glucose level depending on the time course. The most evident effect of carnosine was on serum procollagen III peptide level, which was lowered in infested groups treated with carnosine. Histopathological studies confirmed the potential use of carnosine for intervention in schistosomiasis.


Subject(s)
Carnosine/therapeutic use , Liver/parasitology , Mesocricetus/parasitology , Schistosoma/drug effects , Schistosomiasis mansoni/drug therapy , Alkaline Phosphatase/metabolism , Animals , Aspartate Aminotransferases/metabolism , Collagen Type III/metabolism , Cricetinae , Disease Models, Animal , Female , Granuloma/drug therapy , Granuloma/pathology , Liver/enzymology , Liver/pathology , Male , Schistosoma/metabolism , Schistosomiasis mansoni/enzymology , Schistosomiasis mansoni/pathology , gamma-Glutamyltransferase/metabolism
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