ABSTRACT
Introduction Concha bullosa (CB) is the most common sinonasal anatomical variation reported in literature, it occurs most often in the middle turbinate. Causes of development are not clearly identified but coincident prevalence with deviated nasal septum (DS) is common. Objective To study the relationship between DS and development of CB. Methods A prospective study including 40 patients with DS, CT scans were thoroughly analyzed to detect the presence of CB, its type, and laterality. Effect of degree of septal deviation from the midline and level of deviation in the axial plane were also addressed. Results The study included 40 patients with DS; 15 of them had associated CB; the lamellar type of CB was the most prevalent followed by the true type. Conclusion Incidence of CB was higher in patients with increased angle of septal deviation and with lower level of deviation in the axial plane.
ABSTRACT
Rhinoscleroma (RS) is a chronic specific disease of nose and upper respiratory passages caused by Klebsiella rhinoscleromatis bacilli. It is endemic in Egypt and in sporadic areas worldwide. Diagnosis of RS depends on identification of the pathognomonic Mickulicz cells (MCs) which is most prominent during granulomatous phase but spares or absent during catarrhal or sclerotic phases of the disease. This study aimed to identify the potential diagnostic features of nasal RS when MCs are absent. Nasal biopsies from 125 patients complaining of chronic nasal symptoms were retrieved for this study; including 72 chronic non specific inflammatory lesions and 53 RS diagnosed by PAS and Geimsa stains. The detailed histological differences among the two groups were measured statistically. RS was frequently a bilateral disease (P < 0.05) of young age (P < 0.001) with a female predominance (P < 0.05) and usually associated with nasal crustations (P < 0.001). Five strong histological indicators of RS were specified by univariate binary logistic regression analyses including squamous metaplasia (OR 27.2, P < 0.0001), dominance of plasma cells (OR 12.75, P < 0.0001), Russell bodies (OR 8.83, P < 0.0001), neutrophiles (OR 3.7, P < 0.001) and absence of oesinophiles (OR 12.0, P < 0.0001). According to Multivariate analysis, the diagnostic features of RS in absence of MCs can be classified into major criteria including dominance of plasma cells infiltration and absence of oesinophiles and minor criteria including young age, female gender, bilateral nasal involvement, nasal crustation, squamous metaplasia, Russell bodies, and neutrophiles. The diagnostic model using the two major criteria confirmed or excluded RS in 84.3% of the investigated cases.
