Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Genet Mol Res ; 12(4): 5851-7, 2013 Nov 22.
Article in English | MEDLINE | ID: mdl-24301954

ABSTRACT

Most studies have used in vitro systems to test inflammatory responses of nanoparticles; these may not reflect the real biological response of body organs. In fact, certain nanoparticles have provoked opposite effects under in vitro and in vivo conditions. Current understanding of the biocompatibility of gold nanoparticles is controversial. We studied the acute (1 day) and sub-chronic (5 days) effects of gold nanoparticles (10 and 50 nm in diameter) on expression of interleukin-1 beta (IL-1ß), IL-6 and tumor necrosis factor alpha (TNF-α) in rat liver. Real-time PCR analysis showed that gold nanoparticles of both sizes significantly increased cytokine gene expression on day 1; this had subsided by day 5. The 50-nm gold nanoparticle produced more severe inflammation than the smaller gold nanoparticle. These findings indicate a possible biocompatibility of medium-sized gold nanoparticles, as they caused only a transient increase in proinflammatory cytokines, followed by normalization during sub-chronic repeated exposure.


Subject(s)
Interleukin-1beta/metabolism , Interleukin-6/metabolism , Liver/metabolism , Metal Nanoparticles/adverse effects , Tumor Necrosis Factor-alpha/metabolism , Animals , Gold/chemistry , Gold/pharmacology , Inflammation/chemically induced , Inflammation/metabolism , Interleukin-1beta/genetics , Interleukin-6/genetics , Liver/drug effects , Male , Rats , Rats, Wistar , Tumor Necrosis Factor-alpha/genetics
SELECTION OF CITATIONS
SEARCH DETAIL
...