ABSTRACT
The diagnostic significance of serum markers of fibrosis was investigated in 92 patients with chronic viral hepatitis (CVH) by studying the collagenolythic activity of blood, proteasic inhibitor activity, collagen metabolism products (oxyproline fraction), and fibronectin. At the same time, the patients underwent puncture biopsy of the liver, which made it possible to determine the degree of process activity and the stage of its chronization. As the degree of fibrosis grew, the collagenase serum activity increased significantly, while the alpha1-proteinase inhibitor activity fell, the content of oxyproline (its fractions) increased, and the fibronectin level decreased. Hence, the measurement of the noted parameters allows for noninvasive diagnostics of CVH stages.
Subject(s)
Biomarkers/blood , Collagenases/blood , Hepatitis, Viral, Human/blood , Adolescent , Adult , Biopsy , Chronic Disease , Disease Progression , Female , Hepatitis, Viral, Human/diagnosis , Humans , Male , Middle Aged , PrognosisABSTRACT
The researchers evaluated the condition of lipid peroxidation and antioxidant protection system together with biochemical, immunological and morphological values in 117 patients with chronic hepatitis (CH) in virus replication phase (28 patient had CH type B, 66--CH type C and 28--CH type B+C), and estimated the importance of their interrelations to the prediction of disease outcomes.
Subject(s)
Antioxidants/metabolism , Hepatitis B, Chronic/metabolism , Hepatitis C, Chronic/metabolism , Lipid Peroxidation , Adolescent , Adult , Aged , Female , Hepatitis B, Chronic/pathology , Hepatitis C, Chronic/pathology , Humans , Male , Middle Aged , Predictive Value of Tests , Treatment OutcomeABSTRACT
A hundred and one patients with chronic viral hepatitis (CVH) in the phase of replication were examined. Group 1 comprised 53 patients with CVH in combination with chronic opisthorchiasis. Group 2 (a comparison group) included 48 patients with CVH without opisthorchiasis. According to the etiology of hepatitis, each group was divided into 3 subgroups: subgroups 1a and 2a consisted of patients with CVHB; 1b and 2b included those with CVHC, and 1c and 2c comprised those with CVHB+C. The clinical, functional, and morphological status of the liver was studied and hepatic tissue was qualitatively and quantitatively assessed in all the examinees. The findings suggest that Opisthorchis is an additional factor that aggravates hepatic damage in patients with CVH in the replicative phase of infection.
