[Peripheral blood morphology during chronic bronchitis complicated by the effect of ozone]. / Morfologiia perifericheskoi krovi pri khronicheskom bronkhite, oslozhnennom deistviem ozona.

In workers afflicted with chronic bronchitis (ChB) after breathing ozone leukocytosis gives place to leukopenia against development of lympho-, monocyto- and neutropenia. In contrast to the workers, in citizens who have not previously contacted ozone chronic obstructive bronchitis is characterized by leukocytosis with less expressed lympho- and neutropenia. Changes in peripheral blood in ChB patients (development of leuko-, lympho-, monocyto- and neutropenia) grow drastically in 5-8 years of ozone inhalation.

Lipid peroxidation--antioxidant activity system in erythrocytes of patients with chronic bronchitis inhaling and not inhaling ozone.

Development of chronic bronchitis in individuals chronically exposed to ozone is associated with complex changes in the lipid peroxidation--antioxidant activity system in erythrocytes characterized by intensification of lipid peroxidation and parallel attenuation of antioxidant activity.

Functional insufficiency of the system responsible for reactive oxygen species generation by blood neutrophils.

We studied functional activity of the system responsible for generation of reactive oxygen species by blood neutrophils and involved in pathophysiological mechanisms of bronchopulmonary diseases. Insufficiency of this system can be classified as relative, latent (type I and II), and severe.

[On some basic issues and factorial structure of ecological pulmonology]. / Nekotorye obshchie voprosy y faktorial'naia struktura ékologicheskoi pul'monologii.

Consideration is given to the place occupied by diseases of respiratory organs in the general structure of morbidity. In many ways, growth in their number has been determined by amplification of anthropogenic factors. This is manifested in emergence of new eco-dependent diseases and syndromes including more difficult course of pulmonary pathology. One of the prioritized disciplines of the modern pulmonology is ecological pulmonology which lies in the domain of medical ecology and is central to the concept of eco-dependent human diseases. A factorial structure of ecological pulmonology built on the etiological principle is proposed to facilitate inquiry into the origin and course of various forms of eco-dependent pathology of the lung.

Effects of antibiotics on reactive oxygen species generation by neutrophils.

Antibiotic therapy of patients with exacerbation of chronic obstructive bronchitis exposed and not exposed to ozone did not improve oxidative metabolism in neutrophils. Cefazolin, ceftizoxime, and gentamicin normalized functional biocidal reserves of neutrophils, which correlated with pronounced therapeutic effects.

Effect of long-term exposure to ozone on functional activity of human phagocytes.

Functional activity (biocidal properties) of whole blood phagocytes from humans exposed to ozone was studied by measuring spontaneous and zymosan-induced luminol-dependent chemiluminescence. Generation of reactive oxygen species and biocidal properties of phagocytes depended on the time of ozone exposure and development of bronchopulmonary diseases. The data suggest that generation of reactive oxygen species must be assayed for elaboration of individual patient management programs.

[Comparative study of ion homeostasis and lipid peroxidation in human serum during prolonged exposure to ozone]. / Sravnitel'noe izuchenie ionnogo gomeostaza i perekisnogo okisleniia lipidov v syvorotke krovi cheloveka pri dlitel'nom deistvii ozona.

Concentrations of the ions of calcium, sodium, potassium, chloride-anions and end-products of lipid peroxidation in blood serum of patients with bronchopulmonary pathologies were investigated on a background of prolonged exposure in ozone. Ion homeostasis was found to alter as products of lipid peroxidation accumulated. Suppositions regarding possible mechanisms of impairment of ion homeostasis were made.