THE EFFECT OF NOS3 AND AGTR1 GENOTYPES ON THE COURSE OF THE ARTERIAL HYPERTENSION FOR THE OVERWEIGHT OR OBESE PATIENTS.

OBJECTIVE: The aim: Objective of the research is to determine the effect of NOS3 and AGTR1 genotypes of patients with arterial hypertension and high body mass index in the course of the disease. PATIENTS AND METHODS: Materials and methods: 58 patients (22 men and 36 women) with AH and high BMI were examined. The average age of the examined patients was 53.6±8.7 years. The analysis of rs1799983 polymorphisms of the NOS3 gene (localization 7q36.1; 7:150999023) and AGTR1 (type 1 receptor for angiotensin 2 1166 A>C) was performed using TaqMan assay (Thermo Fisher Scientific, USA) by real-time PCR (Applied Biosystems, USA) using TaqMan probe amplification products. Genomic DNA samples were isolated from stabilized blood using a Genomic DNA Mini Kit reagent (Invitrogen, USA). The Statistica 10 program (StatSoft Inc.) was used for statistical processing of the obtained data, USA). The independent samples were compared using the Mann-Whitney (U) criterion. In all cases of statistical evaluation, the reliability of differences was taken into account at a value of p<0.05. CONCLUSION: Results and conclusions: Polymorphism of the NOS3 and AGTR1 genes is associated with early development and complicated course of cardiovascular pathology. The combination of NOS3 and AGTR1 gene polymorphism in patients with the high body mass index increases the risk of complications in hypertension. Using a mathematical model to predict the probability (95%) of genetic mutations in two genes (NOS3 and AGTR1) increases the effectiveness of diagnosis for patients with the high risk of developing cardiovascular complications.

Phenomenon of self-destructive behavior in female sex workers: discriptors, predictors, typology, psychological correction.

OBJECTIVE: Introduction: Engaging in sex, which is obligatory associated with the extraordinary risks of harm to their own safety and physical health, can be considered as one of the variants of self-destruction. The aim is to analyze the leading descriptors and predictors of self-destructive behavior among female sex workers, on the basis of which to propose measures for their psycho-correction. PATIENTS AND METHODS: Materials and methods: The main group of the study was 135 women - female sex workers, a comparative group of 50 women who had no relation to such activities. The research methods were clinical-psychological, socio-demographic, psycho diagnostic, mathematical-statistical. RESULTS: Results: Suicidal mood was investigated as a descriptor of self-destructive behavior in female sex workers. Features of suicidal ideas and the basis of committing suicide are revealed. The motivating emotions of a suicidal act are shame, anger and resentment. Psychological protection as a mechanism for maintaining risky sexual behavior has been studied. Identified destructive forms of primitive level mechanisms of psychological defense. It was revealed that in women engaged in prostitution the overall viability is not sufficiently formed, mainly due to the low level of inclusion. The presence of sacrifice in the form of increased propensity to active victim behavior has been established. An increased tendency toward an active type of victim behavior has been established. Leading individual psychological and behavioral patterns in the genesis of self-destructive behavior in female sex workers have been identified and its clinical and psychological options have been singled out. Based on the data obtained, a program of measures for differentiated psycho-correction of self-destructive behavior among female sex workers was developed. CONCLUSION: Conclusions: As a result of work, the conceptualization of occupation of prostitution as a self-destructive behavior is grounded. The isolation of its specific pathognomonic psycho-emotional, individual psychological and behavioral features, made it possible to propose effective measures of its psycho-correction and of psycho-processing.