ABSTRACT
BACKGROUND: The usefulness of fine needle aspiration technique for cytology diagnosis of lymph node lesions has been a subject of controversy over years. OBJECTIVE: This study aims to determine the accuracy of this technique in the diagnosis of peripheral lymph node lesions, in our center, using histology diagnosis as a gold standard. METHODS: The cytopathological diagnosis of 49 cases of peripheral lymph node lesions seen in the Morbid Anatomy Department of the Lagos University Teaching Hospital, Lagos from Jan. 2000 to December 2009 were compared with their corresponding histological diagnosis. Lymph node lesions were categorized into inflammatory, Hodgkin's lymphoma, Non Hodgkin's lymphoma and metastatic. The sensitivity, specificity and positive as well as the negative predictive values of the technique were determined. RESULTS: The overall sensitivity, specificity and positive and negative predictive values were 79.6%, 95.9.0%, 79.6% and 95.9% respectively. For non neoplastic lesions, FNAC has a high false negative report. For primary lymphoid neoplasm, the sensitivity, specificity and both predictive values were above 80% while the procedure produced sensitivity and specificity values of 100 and 97.1 percent respectively in the diagnosis of metastatic lesions. CONCLUSION: Despite the pitfalls and limitations of the procedure, the study demonstrated that fine-needle aspiration is a valuable tool for the evaluation of peripheral adenopathy. But FNAC technique for cytological diagnosis of lymphoid lesions using H and E and Giemsa stains alone cannot be used as the sole diagnosis of lymphoid enlargements. Its accuracy can be improved with the availability immunocytochemistry and flow cytometry.
Subject(s)
Biopsy, Fine-Needle/methods , Lymph Nodes/pathology , Adolescent , Adult , Age Distribution , Aged , Biopsy, Fine-Needle/standards , Child , Child, Preschool , False Negative Reactions , False Positive Reactions , Female , Hospitals, University , Humans , Infant , Male , Middle Aged , Nigeria , Sensitivity and Specificity , Sex Distribution , Young AdultABSTRACT
BACKGROUND: There is a wide variation in the incidence of childhood tumors world wide. The relative incidence of childhood tumors in developing countries is increasing and might add significantly to the high childhood morbidity and mortality caused by infectious diseases. There is need to determine the incidence of childhood cancer in different centers of the country and contribute to the National cancer register. OBJECTIVE: The aim of this study is to determine the burden and patterns of childhood tumour in our environment. METHODS: A retrospective review of histologically diagnosed cases of childhood tumours seen from January 2000 to 2007 from the records of the Department of Morbid Anatomy of the Lagos University Teaching Hospital (LUTH), Nigeria was carried out. All the cases were analyzed for age and gender distribution as well as histological types. RESULTS: Malignant tumours constituted 30.50% of the tumours of which retinoblastoma is the most common. The most common benign tumour was fibroadenoma accounting for 36.2% of all benign tumours. The female to male ratio for malignant and benign tumours are 1:1 and 1:1.3 respectively. The peak age incidence was 11 - 15 years for benign and 1 - 5 for malignant tumours. CONCLUSION: The study showed decrease in the annual incidence of childhood tumours in Lagos. There was however no difference in the pattern when compared with other centers in Nigeria and in other African countries.
Subject(s)
Hospitals, Teaching/statistics & numerical data , Neoplasms/epidemiology , Neoplasms/pathology , Adolescent , Age Distribution , Child , Child, Preschool , Female , Humans , Incidence , Infant , Infant, Newborn , Male , Neoplasms/classification , Nigeria/epidemiology , Retrospective Studies , Sex Factors , Urban HealthABSTRACT
Background: There is a wide variation in the incidence of childhood tumors world wide. The relative incidence of childhood tumors in developing countries is increasing and might add significantly to the high childhood morbidity and mortality caused by infectious diseases. There is need to determine the incidence of childhood cancer in different centers of the country and contribute to the National cancer register Objective: The aim of this study is to determine the burden and patterns of childhood tumour in our environment. Methods: A retrospective review of histologically diagnosed cases of childhood tumours seen from January 2000 to 2007 from the records of the department of Morbid Anatomy of the Lagos University Teaching Hospital (LUTH); Nigeria was carried out. All the cases were analyzed for age and gender distribution as well as histological types Results: Malignant tumours constituted 30.50of the tumours of which retinoblastoma is the most common. The most common benign tumour was fibroadenoma accounting for 36.2of all benign tumours. The female to male ratio for malignant and benign tumours are 1:1 and 1:1.3 respectively. The peak age incidence was 11 - 15 years for benign and 1 - 5 for malignant tumours. . Conclusion: The study showed decrease in the annual incidence of childhood tumours in Lagos. There was however no difference in the pattern when compared with other centers in Nigeria and in other African countries
