ABSTRACT
The characteristic feature of molecular medicine as medicine based on molecular structure of human genome data, is its individual character. It is focused on correcting pathological process in specific individual considering unique characteristics of its genome. The other most important feature is its expressed preventive direction. The complete genome information can be obtained well before the onset of disease. The appropriate preventive measures can completely eliminate or significantly prevent development of severe disease. The establishment of gene network of every multi-factorial disease, identification of central genes and genes-modifiers in it, analysis of association of their alleles with disease, development on this basis of set of preventive measures for specific patient constitute conceptual and methodological basis of predictive medicine. As a result of the examination, information can be obtained concerning particular risk of disease development. The physician, considering the results of molecular genetic analysis, elaborates tactics of pathogenetically justified preventive therapy, i.e. corrects congenital metabolic defect.
Subject(s)
Computational Biology , Genomics , Metabolic Syndrome , Humans , Metabolic Syndrome/diagnosis , Metabolic Syndrome/geneticsABSTRACT
Examination, treatment, and postoperative complications in 286 patients with penetrating chest injuries are analysed. Errors in the diagnosis and treatment were disclosed in 104 (36.4%) cases. All of the wounded were operated on, a total of 490 operations were carried out. Complications occurred in 69 (14.1%) patients. Sixteen (5.6%) patients died. Diagnostic errors were made in 28 patients, tactical in 25, technical in 51, faulty postoperative management was revealed in 18 patients. A connection between the errors and complications was established in 52 cases with complications (75.4%). Gross fatal errors were made in 7 of 16 patients who died.
