ABSTRACT
Antecedentes: Estudiar la posible relación entre la expresión inmunohistoquímica del receptor 1 del factor de crecimiento endotelial vascular (VEGFR1) y el valor máximo de captación estandarizada (SUVmáx) de la PET 18F-FDG en pacientes con cáncer de pulmón de células no pequeñas.Material y métodos:El estudio incluyó 39 pacientes con NSCLC (24 carcinomas de células escamosas y 15 adenocarcinomas). Según el estadio clínico, los pacientes se distribuyeron de la siguiente manera: 8 en estadio I, 7 en estadio II, 15 en estadio III y 9 en estadio IV. Se estudió la expresión inmunohistoquímica del VEGFR1 mediante la técnica de la matriz tisular utilizando el dispositivo de arreglo de tejidos (Beecher Instruments, Sun Prairie, WI), utilizando el anticuerpo policlonal contra el VEGFR1 (Santa Cruz Biotechnology, California, EE. UU.).Resultados: Se observó una expresión inmunohistoquímica positiva del VEGFR1 en 23 casos (59%). El número de tumores positivos no se relacionó con el estadio clínico pero hubo una asociación estadísticamente significativa diferente (p: 0,0009) entre la positividad de VEGFR1 y el tipo histológico, correspondiendo los mayores porcentajes de resultados positivos a los adenocarcinomas (93,3%) frente a los carcinomas escamocelulares (37,5%). Asimismo, los valores SUVmáx fueron mayores (p: 0,039) en los carcinomas VEGFR1 negativos que en los tumores VEGFR1 positivos (r: 4-32,1; 16,4+/-6,4 [mediana 16,1] vs. r: 3-47; 14,5+/-8,6 [12,8]).Conclusiones: Nuestros resultados nos llevaron a considerar que en el CPCNP, la expresión inmunohistoquímica negativa de VEGFR1 se asocia significativamente con el subtipo de carcinomas de células escamosas y con valores SUVmáx más altos en 18F-FDG-PET (AU)
Background: To study the possible relation between immunohistochemical expression of vascular endothelial growth factor receptor 1 (VEGFR1) and the maximum standardised uptake value (maxSUV) of 18F-FDG PET in patients with non small cell lung cancer.Material and methods: The study included 39 patients with NSCLC (24 squamous cell carcinomas and 15 adenocarcinomas). According to the clinical stage, the patients were distributed as follows: 8 stage I, 7 stage II, 15 stage III and 9 stage IV. Immunohistochemical expression of VEGFR1 was studied through the technique of tissue-matrix using tissue arrayer device (Beecher Instruments, Sun Prairie, WI), using the polyclonal antibody against VEGFR1 (Santa Cruz Biotechnology, California, USA).Results: Positive VEGFR1 immunohistochemical expression was noted in 23 cases (59%). The number of positive tumours was not related with clinical stage but there was a different statistically significant association (p:.0009) between VEGFR1 positivity and histological type, corresponding the greater percentages of positive results to adenocarcinomas (93.3%) versus in squamous cell carcinomas (37.5%). Likewise, maxSUV values were higher (p: .039) in negative VEGFR1 carcinomas than in positive VEGFR1 tumors (r: 4-32.1; 16.4+/-6.4 [median 16.1] vs. r: 3-47; 14.5+/-8.6 [12.8]).Conclusions: Our results led us to consider that in NSCLC, the negative VEGFR1 immunohistochemical expression is associated significantly with squamous cell carcinomas subtype and with higher maxSUV values in 18F-FDG-PET (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Lung Neoplasms/pathology , Small Cell Lung Carcinoma/pathology , Vascular Endothelial Growth Factor A/analysis , Neoplasm Staging , Immunohistochemistry , Small Cell Lung Carcinoma/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Fluorodeoxyglucose F18 , Radiopharmaceuticals , Positron-Emission Tomography , Biomarkers, Tumor/analysisABSTRACT
BACKGROUND: To study the possible relation between immunohistochemical expression of vascular endothelial growth factor receptor 1 (VEGFR1) and the maximum standardised uptake value (SUV max) of 18F-FDG PET in patients with non small cell lung cancer (NSCLC). MATERIAL AND METHODS: The study included 39 patients with NSCLC (24 squamous cell carcinomas and 15 adenocarcinomas). According to the clinical stage, the patients were distributed as follows: 8 stage I, 7 stage II, 15 stage III and 9 stage IV. Immunohistochemical expression of VEGFR1 was studied through the technique of tissue-matrix using Tissue Arrayer Device (Beecher Instruments, Sun Prairie, WI), using the polyclonal antibody against VEGFR1 (Santa Cruz Biotechnology, California, USA). RESULTS: Positive VEGFR1 immunohistochemical expression was noted in 23 cases (59%). The number of positive tumours was not related with clinical stage but there was a different statistically significant association (p:0,0009) between VEGFR1 positivity and histological type, corresponding the greater percentages of positive results to adenocarcinomas (93,3%) versus in squamous cell carcinomas (37,5%). Likewise, SUV max values were higher (p: 0,039) in negative VEGFR1 carcinomas than in positive VEGFR1 tumors (r: 4-32,1; 16,4+/-6,4 (median 16,1) vs r: 3-47; 14,5+/-8,6 (12,8)). CONCLUSIONS: Our results led us to consider that in NSCLC, the negative VEGFR1 immunohistochemical expression is associated significantly with squamous cell carcinomas subtype and with higher SUV max values in 18F-FDG-PET.
Subject(s)
Carcinoma, Non-Small-Cell Lung , Carcinoma, Squamous Cell , Lung Neoplasms , Vascular Endothelial Growth Factor Receptor-1/genetics , Carcinoma, Non-Small-Cell Lung/diagnostic imaging , Carcinoma, Squamous Cell/diagnostic imaging , Fluorodeoxyglucose F18 , Humans , Lung Neoplasms/diagnostic imaging , Positron-Emission Tomography , RadiopharmaceuticalsABSTRACT
BACKGROUND: To study the possible relation between immunohistochemical expression of vascular endothelial growth factor receptor 1 (VEGFR1) and the maximum standardised uptake value (maxSUV) of 18F-FDG PET in patients with non small cell lung cancer. MATERIAL AND METHODS: The study included 39 patients with NSCLC (24 squamous cell carcinomas and 15 adenocarcinomas). According to the clinical stage, the patients were distributed as follows: 8 stage I, 7 stage II, 15 stage III and 9 stage IV. Immunohistochemical expression of VEGFR1 was studied through the technique of tissue-matrix using tissue arrayer device (Beecher Instruments, Sun Prairie, WI), using the polyclonal antibody against VEGFR1 (Santa Cruz Biotechnology, California, USA). RESULTS: Positive VEGFR1 immunohistochemical expression was noted in 23 cases (59%). The number of positive tumours was not related with clinical stage but there was a different statistically significant association (p:.0009) between VEGFR1 positivity and histological type, corresponding the greater percentages of positive results to adenocarcinomas (93.3%) versus in squamous cell carcinomas (37.5%). Likewise, maxSUV values were higher (p: .039) in negative VEGFR1 carcinomas than in positive VEGFR1 tumors (r: 4-32.1; 16.4+/-6.4 [median 16.1] vs. r: 3-47; 14.5+/-8.6 [12.8]). CONCLUSIONS: Our results led us to consider that in NSCLC, the negative VEGFR1 immunohistochemical expression is associated significantly with squamous cell carcinomas subtype and with higher maxSUV values in 18F-FDG-PET.
ABSTRACT
INTRODUCTION: There have been reports of pneumonitis associated with subcutaneous injection of liquid silicone, and of other pulmonary conditions due to cohesive silicone gel prostheses, but we know of no previous cases of pneumonitis associated with silicone gel. MATERIALS AND METHODS: We report the case of a patient with a cohesive silicone gel mammary prosthesis in whom silicone-induced pneumonitis was diagnosed following radiological observation of pulmonary infiltrates and tests including transbronchial biopsy, which revealed the presence of silicone in alveolar histiocytes and small blood vessels. CONCLUSION: Following removal of the ruptured prosthesis and a course of systemic corticoids, the patient progressed favourably.
Subject(s)
Breast Implants/adverse effects , Pneumonia/chemically induced , Silicone Gels/adverse effects , Adrenal Cortex Hormones/therapeutic use , Anti-Inflammatory Agents/therapeutic use , Female , Glucocorticoids/therapeutic use , Humans , Middle Aged , Pneumonia/drug therapy , Pneumonia/etiology , Pneumonia/surgery , Prednisone/therapeutic use , Radiography , Rupture/complications , Rupture/diagnostic imaging , Rupture/surgery , Silicone Gels/toxicityABSTRACT
Duplication cysts are rare gastrointestinal congenital abnormalities. They can occur anywhere throughout the gastrointestinal tract, and gastric duplication cysts are most uncommon, representing only 4-8% of all gastrointestinal duplication cysts. Nowadays several theories try to explain the pathogenic mechanisms involved. These cysts are usually diagnosed during early childhood, and very rarely are detected in adults, mostly incidentally due to a lack of symptoms. Close to 50% of gastric cysts are associated with other abnormalities. It is extremely important that a meticulous differential diagnosis is performed regarding other diseases, mainly malignancies with a cystic component. Although extremely uncommon, a malignant transformation of these lesions has been reported, which highlights the importance of a correct diagnosis. Herein we report the case of a duplication cyst in an adult, which was detected by endoscopic ultrasound-guided fine-needle aspiration, recently proposed as the most accurate technique for the identification of these lesions.
Subject(s)
Cysts/diagnostic imaging , Cysts/pathology , Gastroscopy , Stomach Neoplasms/diagnostic imaging , Stomach Neoplasms/pathology , Stomach/abnormalities , Adult , Biopsy, Fine-Needle/methods , Humans , Male , Stomach/diagnostic imaging , Stomach/pathology , UltrasonographyABSTRACT
Los quistes de duplicación son anomalías congénitas infrecuentesdel tracto gastrointestinal que pueden localizarse a cualquiernivel desde la boca hasta al ano. Los quistes de duplicación gástricosson los más excepcionales y constituyen tan sólo el 4-8% detodos ellos. Su patogénesis es controvertida y hoy en día aun existenmúltiples teorías que tratan de explicar su mecanismo etiopatogénico.En la mayoría de los casos el diagnóstico se realiza en laprimera infancia y tan sólo en una pequeña proporción se identificanen la edad adulta como un hallazgo incidental, ya que estasentidades suelen ser asintomáticas fuera de la infancia. Casi en lamitad de los casos se asocia a otras malformaciones congénitas yes de vital importancia realizar un minucioso diagnóstico diferencialcon otras entidades, en especial neoplasias con componentequístico. Aunque es extremadamente inusual, se ha publicado ladegeneración neoplásica de estas lesiones, lo que hace más importantesu preciso diagnóstico y estudio citohistológico. En esteartículo se presenta el caso de un quiste de duplicación gástricodiagnosticado en la edad adulta, mediante ultrasonografía endoscópicaasociado a punción-aspirativa, técnica que ha sido recientementepropuesta como la más eficaz para el diagnóstico
Duplication cysts are rare gastrointestinal congenital abnormalities.They can occur anywhere throughout the gastrointestinaltract, and gastric duplication cysts are most uncommon, representingonly 4-8% of all gastrointestinal duplication cysts. Nowadaysseveral theories try to explain the pathogenic mechanismsinvolved. These cysts are usually diagnosed during early childhood,and very rarely are detected in adults, mostly incidentallydue to a lack of symptoms. Close to 50% of gastric cysts are associatedwith other abnormalities. It is extremely important that ameticulous differential diagnosis is performed regarding other diseases,mainly malignancies with a cystic component. Although extremelyuncommon, a malignant transformation of these lesionshas been reported, which highlights the importance of a correctdiagnosis. Herein we report the case of a duplication cyst in anadult, which was detected by endoscopic ultrasound-guided fineneedleaspiration, recently proposed as the most accurate techniquefor the identification of these lesions
Subject(s)
Humans , Male , Adult , Cysts/pathology , Cysts , Gastroscopy , Stomach/abnormalities , Stomach Neoplasms/pathology , Stomach Neoplasms , Biopsy, Fine-Needle/methods , Stomach/pathology , StomachABSTRACT
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Subject(s)
Humans , Female , Aged , Myositis/pathology , Muscle Neoplasms/pathology , PuncturesABSTRACT
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Subject(s)
Male , Middle Aged , Humans , Carcinoma, Hepatocellular/secondary , Liver Neoplasms/pathology , Mouth Neoplasms/secondary , Liver Cirrhosis/pathologySubject(s)
Hodgkin Disease/pathology , Mycosis Fungoides/pathology , Skin Neoplasms/pathology , Aged , Antineoplastic Agents/therapeutic use , Hodgkin Disease/diagnostic imaging , Hodgkin Disease/drug therapy , Humans , Male , Neoplasms, Multiple Primary , Pelvis/diagnostic imaging , Pelvis/pathology , Tomography, X-Ray Computed , Treatment OutcomeABSTRACT
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Subject(s)
Male , Aged , Humans , Hodgkin Disease/diagnosis , Skin Neoplasms/pathology , Lymphoma, T-Cell, Cutaneous/pathology , Mycosis Fungoides/complicationsABSTRACT
Myxopapillary ependymoma of the filum terminale and conus medullaris are relatively common spinal intradural neoplasms in adults, only 8-14% affecting children. We describe a case of a 15-year-old girl with two myxopapillary ependymomas of the filum terminale. Although cases of two such tumours have been described in adults, we have not found any similar paediatric cases in the literature.
