ABSTRACT
The authors analyzed a condition of coronary collateral circulation in infarction-related artery in patients with acute myocardial infarction with rise and without rise of ST segment. The assessment of collateral circulation was made by coronary angiography using Rentop scale. Results of the research showed, that collateral circulation wasn't visualized by angiography in the first hours after acute myocardial infarction with the rise of ST segment. Apparently, this circulation didn't significantly assisted in maintenance of vital capacity of the myocardium in the pool of infarction-related occlusive coronary artery. Visualization of collateral circulation was noted in majority of patients with acute myocardial infarction without the rise of ST segment. Collateral flow was an important alternative source of blood supply of the heart in patients without rise of ST segment in the period of critical reduction of the antegrade blood flow.
Subject(s)
Collateral Circulation , Coronary Vessels , Fractional Flow Reserve, Myocardial , Aged , Coronary Angiography/methods , Coronary Vessels/pathology , Coronary Vessels/physiopathology , Electrocardiography/methods , Female , Humans , Male , Middle Aged , Myocardial Infarction/diagnosis , Myocardial Infarction/physiopathology , Research Design , Statistics as Topic , Time FactorsABSTRACT
The article analyzed no-reflow phenomenon after endovascular recanalization for chronic coronary occlusion. An assessment of antegrade blood flow was made while performing the coronary angiography according to TIMI classification. The Rentrop scale was used for evaluation of retrograde blood flow. The results of investigation showed, that the frequency of occurrence of no-reflow phenomenon after endovascular recanalization in the case of chronic coronary occlusion wasn't higher than 5%. The onset of no-reflow phenomenon after endovascular recanalization in chronic coronary occlusion doesn't depend on the volume of retrograde collateral filling of distal coronary bloodstream. A postponed restoration of antegrade blood flow was possible in patients with previously manifested (Rentrop II-III) retrograde collateral filling of periphery.
Subject(s)
Angioplasty, Balloon, Coronary , Coronary Occlusion , No-Reflow Phenomenon , Angioplasty, Balloon, Coronary/adverse effects , Angioplasty, Balloon, Coronary/methods , Chronic Disease , Coronary Angiography/methods , Coronary Circulation , Coronary Occlusion/diagnosis , Coronary Occlusion/physiopathology , Coronary Occlusion/surgery , Female , Humans , Male , Microvessels/physiopathology , Middle Aged , No-Reflow Phenomenon/etiology , No-Reflow Phenomenon/physiopathology , Stents , Treatment OutcomeABSTRACT
We studied molecular mechanisms of immunoprotective effects of two dipeptides, AB-O and R-1, on cultured human and rat thymic cells. Both dipeptides were shown to increase the expression of lymphocyte differentiation marker CD5 in thymic cells. Dipeptide AB-O induced T-cells precursor differentiation towards CD4(+)T-helpers and its effect was weaker than that of dipeptide R-1. Dipeptide R-1 stimulates differentiation of CD5(+) cells to mature T-helpers and cytotoxic CD8(+) T cells and hence can be considered as a bioactive substance possessing immunomodulator and antiallergic activity.
