ABSTRACT
Department of Traumatology and Orthopedics Almaty Kazakh Medical University of Continuing Education; 4. Moscow Regional Research Clinical Institute, Russia Resume: in this report we present the results on the use of the method of layer-by-layer (LbL) for obtaining antimicrobial coatings for biomedical implants. As the substrates were used silicon titanium implants and silicon plate. For the obtaining multilayer coatings on the surfaces of the samples were used as the polycation--chitosan and polyanion--carboxymethylcellulose sodium. On the surface multilayer were deposited antibacterial preparations: Triclosan-2,4,4'trichloro-2' hydroxyphenyl ether, silver ions and iodine. Microbiological studies were conducted on the museum strains: E. coli, Candida and Staf. Preliminary antibacterial studies on these microorganisms showed high activity multilayer coating containing triclosan.
Subject(s)
Anti-Bacterial Agents/pharmacology , Coated Materials, Biocompatible/pharmacology , Prostheses and Implants , Triclosan/pharmacology , Anti-Bacterial Agents/chemistry , Candida/drug effects , Carboxymethylcellulose Sodium/chemistry , Carboxymethylcellulose Sodium/pharmacology , Chitosan/chemistry , Chitosan/pharmacology , Coated Materials, Biocompatible/chemistry , Escherichia coli/drug effects , Humans , Polyelectrolytes , Polymers/chemistry , Polymers/pharmacology , Silver/chemistry , Silver/pharmacology , Staphylococcus/drug effects , Triclosan/chemistrySubject(s)
Fracture Fixation, Internal/instrumentation , Fractures, Bone/surgery , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle Aged , Radius Fractures/surgery , Ulna Fractures/surgerySubject(s)
Bone Nails , Fracture Fixation, Internal/instrumentation , Fractures, Bone/surgery , Leg Injuries/surgery , Adolescent , Adult , Aged , Child , Female , Humans , Male , Middle AgedABSTRACT
Results of the measurements of intra-articular pressure in 21 patients with closed injuries of the knee and talocrural joints with a compensation manometer AS-2 are presented. In all the examined patients rather high positive pressure resulting from tissue injuries, exudate in the joint cavity and developed edema in the joint area were revealed.
Subject(s)
Ankle Injuries , Knee Injuries/pathology , Adolescent , Adult , Aged , Ankle Joint , Female , Humans , Knee Joint , Male , Middle Aged , PressureABSTRACT
Impairments in collagen metabolism were observed in patients with Dupuytren's contracture. These impairments were manifested as an increased excretion of hydroxyproline with urine and a decrease in content of the amino acid in tissues of aponeurosis palmaris of the patients. The alterations correlated with the damage caused by contracture. Increased catabolism of collagen appears to be the main reason of the metabolic impairments observed in Dupuytren's contracture, considering the opposite direction of changes in hydroxyproline content in urine and in aponeurosis palmaris of the patients. Impairments in collagen metabolism were of considerable importance in Dupuytren's contracture as demonstrated by the correlation between biochemical alterations and severity of the pathology. The Dupuytren's contracture might be considered as a disease affecting the connective tissue.
