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1.
Sci Rep ; 8(1): 4201, 2018 Mar 06.
Article in English | MEDLINE | ID: mdl-29511221

ABSTRACT

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.

2.
Sci Rep ; 8(1): 683, 2018 01 12.
Article in English | MEDLINE | ID: mdl-29330449

ABSTRACT

Honey bees are increasingly important in the pollination of crops and wild plants. Recent reports of the weakening and periodical high losses of managed honey bee colonies have alarmed beekeeper, farmers and scientists. Infestations with the ectoparasitic mite Varroa destructor in combination with its associated viruses have been identified as a crucial driver of these health problems. Although yearly treatments are required to prevent collapses of honey bee colonies, the number of effective acaricides is small and no new active compounds have been registered in the past 25 years. RNAi-based methods were proposed recently as a promising new tool. However, the application of these methods according to published protocols has led to a surprising discovery. Here, we show that the lithium chloride that was used to precipitate RNA and other lithium compounds is highly effective at killing Varroa mites when fed to host bees at low millimolar concentrations. Experiments with caged bees and brood-free artificial swarms consisting of a queen and several thousand bees clearly demonstrate the potential of lithium as miticidal agent with good tolerability in worker bees providing a promising basis for the development of an effective and easy-to-apply control method for mite treatment.


Subject(s)
Bees/parasitology , Lithium Chloride/pharmacology , Varroidae/drug effects , Animals , Female , Lithium Chloride/chemistry , Pilot Projects , RNA/chemistry , RNA/metabolism , RNA Interference , Survival Analysis
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