[Delay of early rejection of intrasplenic pancreatic allotransplants by fractional splenic irradiation in dogs (author's transl)]. / Verzögerung der Frühabstossung von intralienalen Pankreas-Allotransplantaten durch fraktionierte Milzbestrahlung beim Hund.

The influence of local irradiation of the spleen and immunosuppressive drugs (cyclophosphamide and azathioprine) on the rejection of intrasplenic pancreatic allotransplants was studied. Fractional splenic irradiation (once 4000-5000 rad before, twice 500-1000 rad after transplantation) prolonged transplant function from 4,1 to 6,5 days, in combination with immunosuppressive therapy to 8,5 days.

[Therapy and prognosis of testicular tumors: the seminoma, results from radiation therapy in 100 patients (author's transl)]. / Therapie und Prognose der Hodentumoren: Das Seminom. Ergebnisse der Radiotherapie bei 100 Patienten.

Hundred patients with seminoma were irradiated in our clinic between 1963 and 1975. The 5-year survival rate corresponds to the rate of freedom from disease. It amounts to 97% for Stage I, 84% for Stage II, 55% for Stage III, O for Stage IV, and to 85% for all stages. These results are obtained by means of consequent radiation therapy. It is not cleared up wether general prophylactic irradiation improves the prognosis of mediastinal and supraclavicular affections. No complications may be expected on account of therapeutic doses, as the sensitivity to radiation is high. It is possible, on these grounds, in generalized stages, to take into consideration the total-body irradiation with low doses as an alternative to chemotherapy.

[Therapy and prognosis of testicular tumors: the teratocarcinoma, results from 52 patients (author's transl)]. / Therapie und Prognose der Hodentumoren: Das Teratokarzinom. Ergebnisse bei 52 Patienten.

In this retrospective study, the course of the disease was investigated in 52 patients having been irradiated because of malignant teratoma between 1963 and 1975. The patients were ranged as follows: four cases Stage I, thirty cases Stage II, six cases Stage III, twelve cases Stage IV. All histological preparations were graded once more, using the classification of Pugh and Collins. The 5-year survival recovery rates amounted to 100% in Stage I, to 64% in Stage II, to zero in Stage III and IV, and to 47% for all stages. A remarkable difference of the recovery rates in relation to histological findings was observed: MTIA Stage II=83%, all stages=40%; MTIB Stage II=57%, all stages=33%.

[Results from radiation therapy of 68 inoperable brain tumors (1950 to 1975) (author's transl)]. / Ergebnisse der Radiotherapie bei 68 inoperablen Hirntumoren (1950 bis 1975).

68 patients suffering from inoperable brain tumor were irradiated from 1950 to 1975. (In 21 cases the tumor was localized in the bridge, in eight cases in the pineal). When the total treatment dose was considered sufficient (more than 4000 rd) the 5-year survival rate was 42% (n = 47). Quality of life was good in 75% (n = 20) over at more than five years.

[Radiotherapy of salivary gland carcinomas (results from 80 patients)]. / Rolle der Strahlentherapie bei der Behandlung von Speicheldrüsenkarzinomen (Ergebnisse von 80 Patienten)

Of 102 patients irradiated because of a tumor of the salivary glands between 1952 and 1973, 80 cases are evaluated in this paper. 67 tumors were localized in the parotid gland. We found 12 tumors in the submandibular gland, one tumor in the sublingual gland. The tumors turned out to be benign in 17 cases, whereas the remaining 63 tumors evidently proved to be malignant. 28 patients underwent either sole irradiation, or radiation therapy was performed after a subtotal operation the number of the patients only irradiated being very small. In 29 cases radiation therapy followed a radical operation; the remaining 23 patients were sent to us for radiation therapy not earlier than after a single or repeated recurrences following surgical treatment. In 23 patients a local recurrence developed after irradiation. Metastases to the lymph nodes were observed in 24 patients, in 17 cases being already manifest at the beginning of the irradiation. Distant metastases were found in 30 patients, six of these existing already at the beginning of the radiation therapy. Till now, thirty patients died because of their cancerous disease, 13 patients because of intercurrent diseases. The five-year survival recovery rate amounted to 50%, the rate of seven-year survival to 42%. The results of surgery for malignant tumors of the salivary glands are distinctly improved by radiation therapy. Especially the high percentage of recurrences after sole surgical treatment reveals the necessity of postsurgical radiation therapy. For the prevention of local recurrences, however, very high doses have to be delivered to the tumor generally. We recommend 6500 rd as a minimal dose to be applied within five to six weeks. In certain cases, with particularly radioresistant tumors, a local dose of up to 7500 rd may be delivered to a small volume. Irradiation of the highly malignant tumors of salivary glands should encompass the regionary lymph nodes too, even if they are not affected metastatically.

[Radiotherapy results of nasopharyngeal carcinomas (41 patients)]. / Ergebnisse der Strahlentherapie von Nasopharynxkarzinomen (41 Patienten)

5-year cure rates after radiotherapy of nasopharingeal carcinomas in the own patients are reported. The 5-year cure rate in squamous cell carcinoma is about 30% and in lymphoepithelial carcinoma Schmincke-Regaud about 50%. These results are comparable to those which are published in the recent literature. The base of the skull should be included in the high-dose volume even in T1 and T2 cases.

[Place of radiotherapy in therapy of nose and paranasal sinus neoplasms. Results in 63 patients]. / Stellung der Strahlentherapie in der Behandlung von Karzinomen der Nase und Nasennebenhöhlen. Ergebnisse bei 63 Patienten

Therapeutic results in patients with cancer of the nasal cavity and paranasal sinuses of the own clinic are analysed together with some results published in literature. In early cases with cancer of the nasal cavity and cancer of the infrastructure of the maxillary antrum, the results of radiotherapeutic or surgical treatment are equal. In all the other cases -- the majority of the patients -- combined treatment with surgery and high-dose radiotherapy is superior to either treatment modality alone. The 5-year cure rates are: in early cases about 60% and in the other cases about 30%. The distribution of stages in our patients from 1963 to 1973 shows that the majoirty is in a more or less advanced stage of the disease at the time of diagnosis, comparable to earlier reports.

The risk of chronic progressive radiation myelopathy.

Five cases of chronic radiation myelopathy (four of the thoracic and one of the cervical cord) are presented together with a short summary of cases already published. The important influence of the fractionation scheme is stressed. A dose not exceeding 4400 rd in the thoracic myelon (20 X 2000 rd, 5 times per week, plus 10 X 40 rd - or 15 X 200 rd plus 15 X 90 rd, 5 times per week, - or 8 X 330 rd, three times per week, plus 15 X 80 rd 5 times per week) is considered to be a safe limit. In view of the scarcity of adequately documented cases of cervical myelopathy, it is recommended to keep dose limits about 10% lower than in the thoracic region and to avoid high single doses in curative treatments. Hypertension may increase the risk of radiation myelopathy (case nr. 5).