ABSTRACT
The authors report 525 cases of alpha-thalassemia tracked from samples of cord blood proceeded from 12,709 new-borns. With a frequency of 4.13% alpha-thalassemia was frequently in studied population. The lack of symptomatical shapes (Hemoglobin H disease and hydrops foetalis) agree the present theory about the genetic of Black African alpha-thalassemia.
Subject(s)
Thalassemia/epidemiology , Blood Protein Electrophoresis , Cote d'Ivoire/epidemiology , Ethnicity , Female , Fetal Blood/chemistry , Hemoglobins/analysis , Hospitals, University , Humans , Infant, Newborn , Male , Phenotype , Prevalence , Thalassemia/blood , Thalassemia/geneticsABSTRACT
The authors report 44 cases of hemoglobin O Arab share out in 3 phenotypes (A O Arab, C O Arab and S O Arab). The study of this abnormal hemoglobin has allowed the following conclusions: The Hb O Arab is a rare mutant of hemoglobin. The heterozygote form A O Arab and the association Hb C--Hb O Arab do not present any clinical and hematological manifestations. The associations Hb S--Hb O Arab brings about a serious hemoglobinopathy which has clinical and hematological features like the sickle-cell disease (SSFA2).
