ABSTRACT
OBJECTIVE: The benefits of periodic colonoscopic surveillance after curative resection for colon cancer are controversial. We investigated the incidence, size, and time interval to the detection of recurrent adenomatous polyps in patients who have undergone resection of a colorectal cancer. METHODS: In this retrospective study, the records of 351 patients who underwent curative resection for colorectal carcinoma between 1967 and 1991 were reviewed. Sixty-one patients were excluded because of incomplete data. RESULTS: Eighty-seven patients (30%) were found to have had at least one adenoma. Twelve patients had more than five adenomas. The median time to diagnosis was 24 months. Forty-six patients of the 87 (52.9%) had polyp recurrences within 2 yr after cancer resection. CONCLUSION: This group of patients is at increased risk for the development of adenomatous polyps. Surveillance colonoscopy and polypectomy may reduce the incidence of metachronous colon cancer.
Subject(s)
Adenomatous Polyps/epidemiology , Colonic Polyps/epidemiology , Colorectal Neoplasms/surgery , Neoplasms, Second Primary/epidemiology , Adenomatous Polyps/diagnosis , Aged , Colonic Polyps/diagnosis , Colonoscopy , Female , Follow-Up Studies , Humans , Incidence , Male , Neoplasms, Second Primary/diagnosis , Retrospective Studies , Risk Factors , Time FactorsSubject(s)
Antineoplastic Agents/therapeutic use , Carcinoma, Renal Cell/drug therapy , Kidney Neoplasms/drug therapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Carcinoma, Renal Cell/mortality , Clinical Trials, Phase II as Topic/statistics & numerical data , Drug Resistance , Female , Humans , Incidence , Kidney Neoplasms/epidemiology , Kidney Neoplasms/mortality , Male , Survival Rate , Treatment OutcomeABSTRACT
Carcinoma of the gallbladder is a rare malignancy, with an incidence rate in the United States of 2.2 to 4.4 per 100,000 persons. Its clinical presentation is nonspecific, and the majority of patients have advanced disease at presentation. The diagnosis is rarely made preoperatively. About 90% of gallbladder cancers are adenocarcinomas. Surgical treatment is curative for lesions localized to the mucosa and submucosa, but these represent only about 16% of all gallbladder carcinomas. The role of radical surgery with node dissection and liver resection is controversial. Chemotherapy and radiation therapy do not have a major role in the treatment of gallbladder carcinoma. The prognosis is very poor, with a 5-year survival rate of less than 5%.
