ABSTRACT
Serum specimens from 52 myasthenic patients with thymoma of various histological characteristics and 4 patients with thymoma without myasthenia have tested for anti-Titin-antibodies titer. It has been demonstrated that organ-specific thymoma dominated at myasthenic patients, and organ-nonspecific thymoma - at the patients without myasthenia. There was no correlation between severe clinical symptoms and the level of anti-Titin-antibodies. The titer of antibodies at the patients with organ-specific thymoma was higher that at ones with organ-nonspecific thymoma, but there was no correlation between the level of anti-Titin-antibodies and histological type of organ-specific thymoma.
Subject(s)
Antibodies, Neoplasm/immunology , Biomarkers, Tumor/immunology , Membrane Proteins/immunology , Muscle Proteins/immunology , Myasthenia Gravis/immunology , Protein Kinases/immunology , Thymoma/immunology , Thymus Neoplasms/immunology , Adult , Aged , Connectin , Female , Follow-Up Studies , Humans , Immunoenzyme Techniques , Male , Middle Aged , Myasthenia Gravis/etiology , Severity of Illness Index , Thymoma/complications , Thymoma/pathology , Thymus Neoplasms/complications , Thymus Neoplasms/pathologyABSTRACT
The experience in more than 2000 surgeries on the lungs is analyzed. Recently intraoperative ultrasonic and laser autofluorescent spectroscopic revision of tumors of the lungs and mediastinal organs is successfully used. Intrasurgical ultrasonic examination of the lungs permits to detect the structure and diffusion of primary lung tumor (invasion of vessels) that influences policy of treatment. Optical spectroscopy permits one to carry out intraoperative rapid diagnosis of benign and malignant lung tumors.
Subject(s)
Carcinoma, Squamous Cell/diagnosis , Lung Neoplasms/diagnosis , Lung/diagnostic imaging , Monitoring, Intraoperative , Pneumonectomy , Carcinoma, Squamous Cell/surgery , Diagnosis, Differential , Humans , Lasers , Lung/pathology , Lung Neoplasms/surgery , Male , Middle Aged , Neoplasm Staging , Spectrometry, Fluorescence/methods , UltrasonographyABSTRACT
Differential diagnosis of diseases manifested with lung diffuse dissemination syndrome is very difficult. Final diagnosis is possible only after pathologic examination of specimens taken during diagnostic surgical procedures. Results of open and videothoracoscopic lung biopsy at 107 patients are analyzed. Assessment of surgical trauma was based on respiratory function, neuroendocrine system response and doses of analgesics in postoperative period.
Subject(s)
Intraoperative Complications/diagnosis , Lung Diseases, Interstitial/surgery , Adult , Aged , Analgesics/therapeutic use , Biopsy , Female , Humans , Lung/pathology , Lung/surgery , Lung Diseases, Interstitial/pathology , Male , Middle Aged , Pain, Postoperative/drug therapy , Severity of Illness Index , Thoracic Surgery, Video-AssistedABSTRACT
The results of complex examination and treatment of 376 patients with different diseases of the lungs and pleura were analyzed. High-frequency ultrasound was used in 256 patients for diagnosis of lungs and pleura surgical diseases, 412 ultrasonic examinations were performed. Intraoperative treatment of pleura with low-frequency ultrasound was carried out 134 times for prophylaxis and treatment of acute postoperative pleura empyema in 120 patients operated on for malignant tumors and chronic purulent diseases of the lungs. High efficacy of high-frequency ultrasound for diagnosis of pleura empyema, diffuse and encapsulated pleurisy is demonstrated. Ultrasound-assisted pleural punctures an transthoracic aspiration biopsies permit to avoid complications. Ultrasonic examination of the lungs during surgery in patient suspected of lung cancer permits to study tumor structure. Treatment of pleura with low-frequency ultrasound and combination of this method with photodynamic therapy promote reliable sanation of pleural cavity. Limited rethoracotomy and treatment of pleura with low-frequency ultrasound is the method of choice in the treatment of acute postoperative empyema when there is no effect of conservative treatment.
