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1.
Phys Med Biol ; 56(18): 5805-21, 2011 Sep 21.
Article in English | MEDLINE | ID: mdl-21846934

ABSTRACT

In scintillation dosimetry, a Cerenkov background signal is generated when a conventional fibre optic is exposed to radiation produced by a megavoltage linear accelerator. Three methods of measuring dose in the presence of Cerenkov background are compared. In the first method, a second background fibre is used to estimate the Cerenkov signal in the signal fibre. In the second method, a colour camera is used to measure the combined scintillation and Cerenkov light in two wavelength ranges and a mathematical process is used to extract the scintillation signal. In the third method, a hollow air core light guide is used to carry the scintillation signal through the primary radiation field. In this paper, the strengths and weaknesses of each dosimetry system are identified and recommendations for the optimum method for common clinical dosimetry situations are made.


Subject(s)
Neoplasms/radiotherapy , Radiometry/methods , Scintillation Counting/methods , Equipment Design , Fiber Optic Technology/instrumentation , Fiber Optic Technology/methods , Humans , Neoplasms/pathology , Particle Accelerators/instrumentation , Radiometry/instrumentation , Radiotherapy Dosage , Reproducibility of Results , Scintillation Counting/instrumentation
2.
J Neurosci Methods ; 136(2): 141-9, 2004 Jul 30.
Article in English | MEDLINE | ID: mdl-15183266

ABSTRACT

A new apparatus has been developed to study the control of mastication in humans. The subject places his/her teeth on fixed upper and mobile lower bite plates; the device then enables opening and closing movements of the lower jaw against a controlled resistance. It is also possible to vary the number of teeth in contact with the device during an experiment from the entire dental arcade to a single tooth. The specially designed lower bite plate is dynamic and allows for both rotation and translation of the lower jaw during movement, thus, permitting the natural curvilinear trajectory of the jaw. The lower bite plate can follow chewing initiated by the subject without resisting the movement ('no force' mode) via a dedicated microprocessor controlled compensation mechanism. Another function of the device is to inject a constant predetermined load onto the lower bite plate so that the subject 'chews' against a fixed resistance simulating rapidly yielding food bolus ('fixed force' mode). The device can be programmed to increase or decrease the force during the closing or opening phase of chewing by feeding the position information into the force compensation system so both position and force change in parallel, hence, simulating a bite onto a non-yielding, or sticky, food bolus ('normal chewing' mode). By use of a jaw position compensation mechanism, the device can actively move the lower jaw, following any imposed position pattern ('position controlled' mode). The chewing simulator also has a mode that holds the position at a fixed level and allows the force to change ('position hold' mode). Furthermore, the device can inject additional rapid or slow forces or displacements onto the lower bite plate in order to elicit reflexes so that the response of jaw muscles to such stimuli can be examined at various jaw positions, force levels, phases of motion and velocities. The different modes of the apparatus can be used to study the operation and feedback control of human mastication; in particular whether modulations in jaw muscle activity and reflexes are due to changes in force, velocity, position, chewing cycle phase or a combination of these factors.


Subject(s)
Bite Force , Mastication/physiology , Masticatory Muscles/physiology , Robotics/instrumentation , Transducers/standards , Afferent Pathways/physiology , Electromyography/instrumentation , Electromyography/methods , Feedback/physiology , Humans , Masticatory Muscles/innervation , Mechanoreceptors/physiology , Reflex/physiology , Robotics/methods , Signal Processing, Computer-Assisted/instrumentation , Transducers/trends , Trigeminal Nerve/physiology , Weight-Bearing/physiology
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